ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Increased Prefrontal Activity with Aging Reflects Nonspecific Neural Responses Rather than Compensation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
94 citing papers in PubMed, 166 citations in OpenAlex.
- Optimizing tACS for working memory: differential outcomes in healthy aging and non-amnestic mild cognitive impairment.Alzheimer's research & therapy · 2025Trial
- Synaptic Mitochondrial Oxidative Stress Contributes to Individual Variability in Age-Related Cognitive Inflexibility in Mice.Aging cell · 2026Article
- Electrophysiological correlates of cognitive reserve in healthy older adults at different cognitive states.Cognitive, affective & behavioral neuroscience · 2026Article
- Anxiety, stress, and affective modulation on object-location memory: A systematic review in virtual environments.Cognitive, affective & behavioral neuroscience · 2026Article
- Association of Malaysian-MIND Diet Scores with Brain Activation in Older Adults: A Functional MRI Study.Biomedicines · 2026Article
- Fifteen years on: a review of the Cam-CAN study of the cognitive neuroscience of ageing.GeroScience · 2026Review
- Interplay Between Autophagy, Cellular Senescence, and Brain Aging: Neuroprotective Implications of Intermittent Fasting.Cellular and molecular neurobiology · 2026Review
- Charting Decodability of Dynamic Facial Expressions in Young and Old Adults: Similarities and Differences.Experimental neurobiology · 2025Article
- Evidence of Embodiment-based changes in older Adult Language.Psychological research · 2025Review
- Changing cognitive chimera states in human brain networks with age: Variations in cognitive integration and segregation.PLoS computational biology · 2025Article
- Cortical Activity During Postural Recovery Under Dual-task Conditions: A Quantitative EEG Study.Basic and clinical neuroscience · 2025Article
- CaMK modulates sensory neural activity to control longevity and proteostasis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A Novel Working Memory Task-Induced EEG Response (WM-TIER) Feature Extraction Framework for Detecting Alzheimer's Disease and Mild Cognitive Impairment.Biosensors · 2025Article
- Article
- Different association patterns of emotion regulation and heart rate variability in older and younger adults.Brain communications · 2025Article
- When age tips the balance: A dual mechanism affecting hemispheric specialization for language.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Aging disrupts locus coeruleus-driven norepinephrine transmission in the prefrontal cortex: Implications for cognitive and motor decline.Aging cell · 2025Article
- Singing for memory: neural and cognitive effects of a choral intervention in older adults.Frontiers in aging neuroscience · 2025Article
- Working memory related brain-behavior associations in the context of socioeconomic and psychosocial deprivation.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Cerebral blood flow regulation and cognitive performance in hypertension.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Elevated prefrontal cortex activity is often observed in healthy older adults despite declines in their memory and other cognitive functions. According to one view, this activity reflects a compensatory functional posterior-to-anterior shift, which contributes to maintenance of cognitive performance when posterior cortical function is impaired. Alternatively, the increased prefrontal activity may be less efficient or less specific because of structural and neurochemical changes accompanying aging. These accounts are difficult to distinguish on the basis of average activity levels within brain regions. Instead, we used a novel, model-based multivariate analysis technique applied to two independent fMRI datasets from an adult-lifespan human sample (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.