ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Amplification and Suppression of Distinct Brainwide Activity Patterns by Catecholamines.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
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- Pupillary response is associated with the reset and switching of functional brain networks during salience processing.PLoS computational biology · 2023Article
- The effects of propofol anaesthesia on molecular-enriched networks during resting-state and naturalistic listening.NeuroImage · 2023Article
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- Circuit mechanisms for the chemical modulation of cortex-wide network interactions and behavioral variability.Science advances · 2021Article
- Network structure of the mouse brain connectome with voxel resolution.Science advances · 2020Article
- Editorial: Attention and Methylphenidate.Frontiers in behavioral neuroscience · 2020Article
- Target detection increases pupil diameter and enhances memory for background scenes during multi-tasking.Scientific reports · 2019Article
- Dopamine DThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Atomoxetine and citalopram alter brain network organization in Parkinson's disease.Brain communications · 2019Article
- Commentary: Amplification and Suppression of Distinct Brainwide Activity Patterns by Catecholamines.Frontiers in behavioral neuroscience · 2019Article
- Brainstem Modulation of Large-Scale Intrinsic Cortical Activity Correlations.Frontiers in human neuroscience · 2019Review
- Validating molecular target-enriched fMRI for disentangling drug effects on dopamine.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The widely projecting catecholaminergic (norepinephrine and dopamine) neurotransmitter systems profoundly shape the state of neuronal networks in the forebrain. Current models posit that the effects of catecholaminergic modulation on network dynamics are homogeneous across the brain. However, the brain is equipped with a variety of catecholamine receptors with distinct functional effects and heterogeneous density across brain regions. Consequently, catecholaminergic effects on brainwide network dynamics might be more spatially specific than assumed. We tested this idea through the analysis of fMRI measurements performed in humans (19 females, 5 males) at "rest" under pharmacological (atomoxetine-induced) elevation of catecholamine levels. We used a linear decomposition technique to identify spatial patterns of correlated fMRI signal fluctuations that were either increased or decreased by atomoxetine. This yielded two distinct spatial patterns, each expressing reliable and specific drug effects. The spatial structure of both fluctuation patterns resembled the spatial distribution of the expression of catecholamine receptor genes: α
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.