ArticleInfection and immunity2018
The Psoriasis Risk Allele
Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Microbiological Evaluation of Upper Respiratory Tract Specimens in Patients with Plaque Psoriasis and Psoriatic Arthritis: A Retrospective Study.Pathogens (Basel, Switzerland) · 2026Article
- Integrated Host Genetics and Skin Microbiome Profiling Suggest an HLA-C-Peptostreptococcus Axis in Psoriasis.International journal of molecular sciences · 2026Article
- The impact of antibiotic therapy in psoriasis patients with active streptococcal infection: A prospective study.The Journal of dermatology · 2025Article
- A partitioned polygenic risk score reveals distinct contributions to psoriasis clinical phenotypes across a multi-ethnic cohort.Journal of translational medicine · 2024Article
- Triggers for the onset and recurrence of psoriasis: a review and update.Cell communication and signaling : CCS · 2024Review
- Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation.Nature communications · 2023Article
- Occurrence of IL-1, IL-10, CD25, CD40, and CD69 in the tissue of palatine tonsils.Postepy dermatologii i alergologii · 2022Article
- Skin Barrier Dysregulation in Psoriasis.International journal of molecular sciences · 2021Review
- A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.Nature genetics · 2021Article
- HLA-Cw1 and Psoriasis.American journal of clinical dermatology · 2021Review
- Microbial-derived antigens and metabolites in spondyloarthritis.Seminars in immunopathology · 2021Review
- Gut-Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions.Microorganisms · 2021Review
- Paediatrics: how to manage pharyngitis in an era of increasing antimicrobial resistance.Drugs in context · 2021Review
- Genetics of leprosy: today and beyond.Human genetics · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pharyngeal tonsillitis is one of the most common upper respiratory tract infections, and group A streptococcus is the most important bacterial pathogen causing it. While most patients experience tonsillitis only rarely, a subset of patients suffers from recurrent or chronic tonsillitis or pharyngitis. The predisposing factors for recurring or chronic forms of this disease are not yet fully understood, but genetic predisposition has been suggested. A genetic association study using Illumina's Immunochip single-nucleotide polymorphism (SNP) array was performed to search for new genetic biomarkers in pharyngeal tonsillitis. More than 100,000 SNPs relevant to immune-mediated diseases were analyzed in a cohort of 95 patients subjected to tonsillectomy due to recurrent/chronic tonsillitis and 504 controls. Genetic association between the cases and controls showed strongest association with two peaks in the HLA locus (odds ratio [OR], 3.7 to 4.7;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.