Trial reportAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2019
Albuminuria and Allograft Failure, Cardiovascular Disease Events, and All-Cause Death in Stable Kidney Transplant Recipients: A Cohort Analysis of the FAVORIT Trial.
Trial report in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Influence of Early Postoperative Basal Insulin Treatment and Post-Transplant Diabetes Mellitus Risk on Health-Related Quality of Life in Kidney Transplant Recipients-An Analysis of Data From a Randomized Controlled Trial.Transplant international : official journal of the European Society for Organ Transplantation · 2023Trial
- Article
- Sodium-Glucose Cotransporter-2 Inhibitor in Diabetic and Nondiabetic Renal Transplant Recipients.Kidney international reports · 2025Article
- The SmartNTx-study: a prospective, randomized controlled trial to investigate additional interventional telemedical management versus standard aftercare in kidney transplant recipients.Frontiers in nephrology · 2025Article
- A nomogram based on contrast-enhanced ultrasound for evaluating the glomerulosclerosis rate in transplanted kidneys.Quantitative imaging in medicine and surgery · 2024Article
- Clinical relevance of postoperative proteinuria for prediction of early renal outcomes after kidney transplantation.Kidney research and clinical practice · 2022Article
- Cardiovascular Risk after Kidney Transplantation: Causes and Current Approaches to a Relevant Burden.Journal of personalized medicine · 2022Review
- Surrogate Endpoints for Late Kidney Transplantation Failure.Transplant international : official journal of the European Society for Organ Transplantation · 2022Article
- Allograft Function as Endpoint for Clinical Trials in Kidney Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2022Article
- Meat intake and risk of mortality and graft failure in kidney transplant recipients.The American journal of clinical nutrition · 2021Article
- Early postoperative urinary MCP-1 as a potential biomarker predicting acute rejection in living donor kidney transplantation: a prospective cohort study.Scientific reports · 2021Article
- Association of obesity and muscle mass with risk of albuminuria in renal transplant recipients.Journal of nephrology · 2021Article
- Obesity and Post-Transplant Diabetes Mellitus in Kidney Transplantation.Journal of clinical medicine · 2021Review
- Update on Treatment of Hypertension After Renal Transplantation.Current hypertension reports · 2021Review
- Article
- The predictive value of urinary kidney injury molecular-1 for long-term graft function in kidney transplant patients: a prospective study.Annals of translational medicine · 2021Article
- Microalbuminuria After Kidney Transplantation Predicts Cardiovascular Morbidity.Frontiers in medicine · 2021Article
- Temporal changes of proteinuria after kidney transplantation: association with cardiovascular morbidity and mortality.Journal of nephrology · 2020Article
- The Estimation Formula for the Urinary Albumin-Creatinine Ratio Based on the Protein-Creatinine Ratio Are Not Valid for a Kidney Transplant and a Living Donor Cohort.Journal of the American Society of Nephrology : JASN · 2020Article
- Everolimus in kidney transplant recipients at high cardiovascular risk: a narrative review.Journal of nephrology · 2020Review
Corrections and comments
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Authors and funding
19 authors at 13 institutions in 2 countries.
Funding
Abstract
RATIONALE &
objectiveCardiovascular disease (CVD) is common and overall graft survival is suboptimal among kidney transplant recipients. Although albuminuria is a known risk factor for adverse outcomes among persons with native chronic kidney disease, the relationship of albuminuria with cardiovascular and kidney outcomes in transplant recipients is uncertain. STUDY
designPost hoc longitudinal cohort analysis of the Folic Acid for Vascular Outcomes Reduction in Transplantation (FAVORIT) Trial. SETTING &
participantsStable kidney transplant recipients with elevated homocysteine levels from 30 sites in the United States, Canada, and Brazil. PREDICTOR: Urine albumin-creatinine ratio (ACR) at randomization. OUTCOMES: Allograft failure, CVD, and all-cause death. ANALYTICAL APPROACH: Multivariable Cox models adjusted for age; sex; race; randomized treatment allocation; country; systolic and diastolic blood pressure; history of CVD, diabetes, and hypertension; smoking; cholesterol; body mass index; estimated glomerular filtration rate (eGFR); donor type; transplant vintage; medications; and immunosuppression.
resultsAmong 3,511 participants with complete data, median ACR was 24 (Q1-Q3, 9-98) mg/g, mean eGFR was 49±18 (standard deviation) mL/min/1.73m LIMITATIONS: No data for rejection; single ACR assessment.
conclusionsIn a large population of stable kidney transplant recipients, elevated baseline ACR is independently associated with allograft failure, CVD, and death. Future studies are needed to evaluate whether reducing albuminuria improves these outcomes.
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