ReviewZhongguo fei ai za zhi = Chinese journal of lung cancer2018
[Association between EGFR, ALK and KRAS Gene Status and Synchronous Distant Organ Metastasis in Non-small Cell Lung Cancer].
Review in Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 5 citations in OpenAlex.
- Development of clinical-radiological prediction models to prioritizeJournal of thoracic disease · 2026Article
- Association between KRAS gene polymorphisms and genetic susceptibility to breast cancer in a Chinese population.Journal of clinical laboratory analysis · 2023Article
- Case Report: Genetic profiling of small intestine metastasis from poorly differentiated non-small cell lung cancer: report of 2 cases and literature review of the past 5 years.Frontiers in oncology · 2023Article
- Different clinical features between patients withThe Journal of international medical research · 2021Article
- CA-125, CA-153, and CYFRA21-1 as clinical indicators in male lung cancer with ocular metastasis.Journal of Cancer · 2020Article
- Clinical significance of epithelial-mesenchymal transition-related molecules in lung adenocarcinoma.Current oncology (Toronto, Ont.) · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Lung cancer is the leading cause of morbidity and mortality of malignant diseases in China. Approximately 57% lung cancer patients harbored distant metastases at initial diagnosis which is relevant to poor outcomes. The research strategy of anti-lung cancer metastasis now has became the new treatment directions and thoughts for lung cancer treatment. Previous studies have shown that changes in the corresponding driving genes on different signaling pathways may be related to the transfer of different organs, and the biological alteration of tumor to some extent can affect the metastatic behavior and metastatic pattern of tumor. However, current clinical and basic studies have not elucidated the molecular mechanism of the specific distant organ metastasis in the pathway of lung cancer related signal transduction, clinical research on the correlation between gene mutation and organ transfer specificity is also relatively rare. This review aims to summarize the characteristics of the expression of epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), V-Ki-ras2 Kirsten rat sarcoma viral oncogene homologue (KRAS) in non-small cell lung cancer, and the correlation between the distribution of metastatic organs. .
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