Evidence map›Paper›PMID 30037353›Full record

ArticleActa neuropathologica communications2018

Optic nerve as a source of activated retinal microglia post-injury.

Neal D Heuss, Mark J Pierson, Heidi Roehrich, Scott W McPherson, Andrea L Gram, Ling Li, Dale S Gregerson

Open access · goldAbstract read
In one paragraph

Article in Acta neuropathologica communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Neuroinflammation in glaucoma: a myriad of cellular pathways and players.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Neal D HeussDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.
Mark J PiersonDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.
Heidi RoehrichDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.
Scott W McPhersonDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.
Andrea L GramDepartment of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN, USA.
Ling LiDepartment of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN, USA.
Dale S GregersonDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA. grege001@umn.edu.ORCID 0000-0001-5769-796X
University of Minnesota · US

Funding

Visual TestingP30EY011374 · NEI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI NEWMAN, ERIC A · 1996 to 2019
$8.8M
Dysregulation of Protein Prenylation in the Pathogenesis of Alzheimer's DiseaseRF1AG056976 · NIA · UNIVERSITY OF MINNESOTA · PI DISTEFANO, MARK D, LI, LING · 2017 to 2017
$1.9M
Immune-mediated Neuroprotection of Retinal Ganglion CellsR01EY021003 · NEI · UNIVERSITY OF MINNESOTA · PI GREGERSON, DALE SANNES · 2010 to 2012
$1.3M
Retinal innate immunity: Functional analysis of resident and recruited cellsR01EY025209 · NEI · UNIVERSITY OF MINNESOTA · PI GREGERSON, DALE SANNES · 2016 to 2018
$1.1M
NEI NIH HHS P30 EY011374NEI NIH HHS R01 EY021003NEI NIH HHS R01 EY025209NIA NIH HHS RF1 AG056976
6 · The paper itself

Abstract

Using mice expressing green fluorescent protein (GFP) from a transgenic CD11c promoter we found that a controlled optic nerve crush (ONC) injury attracted GFP

Indexed as

AnimalsCD11c AntigenCX3C Chemokine Receptor 1Disease Models, AnimalKi-67 AntigenLeukocyte Common AntigensLuminescent ProteinsMacrophagesMiceMice, TransgenicMyeloid CellsNeurogliaOptic ChiasmOptic NerveOptic Nerve InjuriesParabiosis2-hydroxy-4,4'-diamidinostilbene, methanesulfonate saltCD11c AntigenCX3C Chemokine Receptor 1Cx3cr1 protein, mouseKi-67 AntigenLeukocyte Common AntigensLuminescent ProteinsStilbamidinesInjury responseMicrogliaMigrationOptic nerveOriginRetina

Identifiers

PMID30037353
PMCPMC6055350
OpenAlexW2884217857

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.