Evidence map›Paper›PMID 30037110›Full record

ArticleToxics2018

Prenatal Exposure to Ambient Pesticides and Preterm Birth and Term Low Birthweight in Agricultural Regions of California.

Chenxiao Ling, Zeyan Liew, Ondine S von Ehrenstein, Julia E Heck, Andrew S Park, Xin Cui, Myles Cockburn, Jun Wu, Beate Ritz

Open access · goldAbstract read
In one paragraph

Article in Toxics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
10.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
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  4. Profiling the cytotoxic effects of naled and other pesticides in primary human placental cytotrophoblasts.Toxicological sciences : an official journal of the Society of Toxicology · 2025
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  18. Comparison of Thyroid Hormone Levels between Women Farmers and Non-Farmers in Banten Indonesia.International journal of environmental research and public health · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Chenxiao LingDepartment of Epidemiology, Fielding School of Public Health, UCLA, Los Angeles, CA 90095, USA. lingcx@ucla.edu.
Zeyan LiewDepartment of Epidemiology, Fielding School of Public Health, UCLA, Los Angeles, CA 90095, USA. zeyanliew@ucla.edu.ORCID 0000-0002-9424-7869
Ondine S von EhrensteinDepartment of Epidemiology, Fielding School of Public Health, UCLA, Los Angeles, CA 90095, USA. ovehren@ucla.edu.
Julia E HeckDepartment of Epidemiology, Fielding School of Public Health, UCLA, Los Angeles, CA 90095, USA. jeheck@ucla.edu.ORCID 0000-0001-8713-8413
Andrew S ParkDepartment of Epidemiology, Fielding School of Public Health, UCLA, Los Angeles, CA 90095, USA. apark1986@ucla.edu.ORCID 0000-0001-5188-4705
Xin CuiDepartment of Epidemiology, Fielding School of Public Health, UCLA, Los Angeles, CA 90095, USA. cynthiacui1010@ucla.edu.ORCID 0000-0002-4277-7972
Myles CockburnDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. myles.cockburn@ucdenver.edu.
Jun WuProgram in Public Health, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA 92697, USA. junwu@uci.edu.
Beate RitzDepartment of Epidemiology, Fielding School of Public Health, UCLA, Los Angeles, CA 90095, USA. britz@ucla.edu.
UCLA Health · USUniversity of California, Irvine · USUniversity of Southern California · US

Funding

Air Pollution and Childhood Cancers in CaliforniaR21ES018960 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HECK, JULIA · 2010 to 2011
$421k
6 · The paper itself

Abstract

Findings from studies of prenatal exposure to pesticides and adverse birth outcomes have been equivocal so far. We examined prenatal exposure to agricultural pesticides in relation to preterm birth and term low birthweight, respectively, in children born between 1998 and 2010, randomly selected from California birth records. We estimated residential exposure to agriculturally applied pesticides within 2 km of residential addresses at birth by pregnancy trimester for 17 individual pesticides and three chemical classes (organophosphates, pyrethroids, and carbamates). Among maternal addresses located within 2 km of any agricultural pesticide application, we identified 24,693 preterm and 220,297 term births, and 4412 term low birthweight and 194,732 term normal birthweight infants. First or second trimester exposure to individual pesticides (e.g., glyphosates, paraquat, imidacloprid) or exposure to 2 or more pesticides in the three chemical classes were associated with a small increase (3⁻7%) in risk for preterm birth; associations were stronger for female offspring. We did not find associations between term low birthweight and exposure to pesticides other than myclobutanil (OR: 1.11; 95% CI: 1.04⁻1.20) and possibly the pyrethroids class. Our improved exposure assessment revealed that first and second trimester exposure to pesticides is associated with preterm delivery but is rarely linked with term low birthweight.

Indexed as

adverse birth outcomesagricultural pesticideslow birthweightpregnancypreterm birthresidential proximity

Identifiers

PMID30037110
PMCPMC6160921
OpenAlexW2883784847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.