ReviewNutrients2018
Dietary Protein and Muscle in Aging People: The Potential Role of the Gut Microbiome.
Review in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 77 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dietary Protein and Skeletal Muscle in Older Twins - Targeting the Gut Microbiome to Overcome Anabolic Resistance: The PROMOTe Study
The Effect of Culinary Medicine to Enhance Protein Intake on Muscle Quality in Older Adults
Who cites it
77 citing papers in PubMed, 3 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Association between dietary diversity and healthy aging: a systematic review.BMC nutrition · 2025Pooled it
- Effect of Sustainably Sourced Protein Consumption on Nutrient Intake and Gut Health in Older Adults: A Systematic Review.Nutrients · 2024Pooled it
- Gut microbiome changes due to sleep disruption in older and younger individuals: a case for sarcopenia?Sleep · 2022Pooled it
- The effect of culinary medicine to enhance protein intake on muscle quality in older adults: a randomized controlled trial.Aging clinical and experimental research · 2025Trial
- The effect of probiotics and casein supplementation on aerobic capacity parameters of male soccer players.Journal of the International Society of Sports Nutrition · 2024Trial
- Effect of gut microbiome modulation on muscle function and cognition: the PROMOTe randomised controlled trial.Nature communications · 2024Trial
- The Gut Microbiome as a Mechanistic Link Between the Planetary Health Diet and Healthy Aging.Nutrients · 2026Review
- Sarcopenia, cachexia and frailty in older cats: Mechanisms, assessment and therapeutic considerations.Journal of feline medicine and surgery · 2026Review
- Association between gut microbiota and sarcopenia in older adults: a cross-sectional analysis from the second wave of the Birjand Longitudinal Aging Study (BLAS).Aging clinical and experimental research · 2026Article
- Longitudinal associations of sarcopenia and biological age acceleration with rate of cognitive decline.BMC public health · 2026Article
- Kampo medicine as a nutrition-relevant multi-target intervention for sarcopenia: implications for appetite, mitochondrial function, and the frailty-sarcopenia-cachexia continuum.Frontiers in nutrition · 2026Review
- Review
- Can Dietary Supplements Support Muscle Function and Physical Activity? A Narrative Review.Nutrients · 2025Review
- Discovery of intestinal microorganisms that affect the improvement of muscle strength.Scientific reports · 2025Article
- The efficacy and safety of fecal microbiota transplantation in the treatment of sarcopenia: a retrospective study.Journal of translational medicine · 2025Article
- Gut microbes-muscle axis in muscle function and meat quality.Science China. Life sciences · 2025Review
- Yeast protein modulates metabolites derived from the human gut microbiota of older male adultsFrontiers in microbiology · 2025Article
- Gut microbiota changes associated with frailty in older adults: A systematic review of observational studies.World journal of clinical cases · 2024Article
- Bifidobacterium animalis Probio-M8 improves sarcopenia physical performance by mitigating creatine restrictions imposed by microbial metabolites.NPJ biofilms and microbiomes · 2024Article
- Dietary amino acids intake and all-cause and cause-specific mortality: results from the Golestan Cohort Study.Nutrition journal · 2024Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Muscle mass, strength, and physical function are known to decline with age. This is associated with the development of geriatric syndromes including sarcopenia and frailty. Dietary protein is essential for skeletal muscle function. Resistance exercise appears to be the most beneficial form of physical activity for preserving skeletal muscle and a synergistic effect has been noted when this is combined with dietary protein. However, older adults have shown evidence of anabolic resistance, where greater amounts of protein are required to stimulate muscle protein synthesis, and response is variable. Thus, the recommended daily amount of protein is greater for older people. The aetiologies and mechanisms responsible for anabolic resistance are not fully understood. The gut microbiota is implicated in many of the postulated mechanisms for anabolic resistance, either directly or indirectly. The gut microbiota change with age, and are influenced by dietary protein. Research also implies a role for the gut microbiome in skeletal muscle function. This leads to the hypothesis that the gut microbiome might modulate individual response to protein in the diet. We summarise the existing evidence for the role of the gut microbiota in anabolic resistance and skeletal muscle in aging people, and introduce the metabolome as a tool to probe this relationship in the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.