Evidence map›Paper›PMID 30036596›Full record

Trial reportThe Journal of allergy and clinical immunology2018

Endogenous bradykinin and B1-B5 during angiotensin-converting enzyme inhibitor-associated angioedema.

Scott A Hubers, Kevin Kohm, Shouzuo Wei, Chang Yu, Hui Nian, Ryan Grabert, Daniel J Sexton, Nancy J Brown

Abstract readLetterRandomized Controlled Trial
In one paragraph

Trial report in The Journal of allergy and clinical immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Angioedema without wheals: a clinical update.Balkan medical journal · 2021
    Article
  6. Review of icatibant use in the Winnipeg Regional Health Authority.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2020
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Scott A HubersDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tenn.
Kevin KohmDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tenn.
Shouzuo WeiDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tenn.
Chang YuDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tenn.
Hui NianDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tenn.
Ryan GrabertGlobal Nonclinical Development, Shire, Lexington, Mass.
Daniel J SextonGlobal Nonclinical Development, Shire, Lexington, Mass.
Nancy J BrownDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tenn. Electronic address: Nancy.j.brown@vanderbilt.edu.

Funding

TIPS: Training in Perioperative ScienceT32GM108554 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire · 2014 to 2026
$3.7M
Pharmacogenetics of ACE inhibitor-associated angioedema R01HL079184 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BROWN, NANCY J. · 2005 to 2014
$3.2M
Cardiovascular Consequences of Peptidase InhibitionR01HL125426 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BROWN, NANCY J. · 2015 to 2019
$2.3M
NHLBI NIH HHS R01 HL079184NHLBI NIH HHS R01 HL125426NIGMS NIH HHS T32 GM108554
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgedAngioedemaAngiotensin-Converting Enzyme InhibitorsBradykininEnalaprilFemaleHumansKininogen, High-Molecular-WeightLisinoprilMaleMiddle AgedPeptide FragmentsQuinaprilAngiotensin-Converting Enzyme InhibitorsBradykininbradykinin (1-5)EnalaprilKininogen, High-Molecular-WeightLisinoprilPeptide FragmentsQuinapril

Identifiers

PMID30036596
PMCPMC6226317

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.