ArticlePloS one2018
Accumulation of bioactive metabolites in cultivated medical Cannabis.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- The Use ofCannabis and cannabinoid research · 2022Pooled it
- Optimizing Photoperiod Switch to Maximize Floral Biomass and Cannabinoid Yield inFrontiers in plant science · 2021Pooled it
- A trio-binning approach for genome assembly reveals extensive structural variation between two Cannabis cultivars: Punto Rojo and Cherry Pie.G3 (Bethesda, Md.) · 2026Article
- Cannabinomics in the flower of Cannabis sativa: a systematic review of extraction, analytical identification, and micro/nanoencapsulation methods for bioactive metabolites.Journal of cannabis research · 2025Review
- Cannabinoids in Integumentary Wound Care: A Systematic Review of Emerging Preclinical and Clinical Evidence.Pharmaceutics · 2024Review
- In Pursuit of Optimal Quality: Cultivar-Specific Drying Approaches for Medicinal Cannabis.Plants (Basel, Switzerland) · 2024Article
- Anti-staphylococcal activity of soilless cultivated cannabis across the whole vegetation cycle under various nutritional treatments in relation to cannabinoid content.Scientific reports · 2024Article
- Solid-State Microwave Drying for Medical Cannabis Inflorescences: A Rapid and Controlled Alternative to Traditional Drying.Cannabis and cannabinoid research · 2024Article
- Building a community-driven bioinformatics platform to facilitateGigaByte (Hong Kong, China) · 2024Article
- Equine Crofton Weed (Animals : an open access journal from MDPI · 2023Review
- Correlations among morphological and biochemical traits in high-cannabidiol hemp (Plant direct · 2023Article
- Hormonal control of promoter activities of Cannabis sativa prenyltransferase 1 and 4 and salicylic acid mediated regulation of cannabinoid biosynthesis.Scientific reports · 2023Article
- Isolation of Biologically Active Compounds fromAntioxidants (Basel, Switzerland) · 2023Article
- Analysis of Cannabinoids in Biological Specimens: An Update.International journal of environmental research and public health · 2023Review
- Article
- Floral hemp (Cannabis sativa L.) responses to nitrogen fertilization under field conditions in the high desert.PloS one · 2023Article
- Secondary Terpenes inBiomedicines · 2022Review
- Profiling Cannabinoid Contents and Expression Levels of Corresponding Biosynthetic Genes in CommercialPlants (Basel, Switzerland) · 2022Article
- Semi-quantitative analysis of cannabinoids in hemp (Cannabis sativa L.) using gas chromatography coupled to mass spectrometry.Journal of cannabis research · 2022Article
- Targeting natural products against SARS-CoV-2.Environmental science and pollution research international · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There has been an increased use of medical Cannabis in the United States of America as more states legalize its use. Complete chemical analyses of this material can vary considerably between producers and is often not fully provided to consumers. As phytochemists in a state with legal medical Cannabis we sought to characterize the accumulation of phytochemicals in material grown by licensed commercial producers. We report the development of a simple extraction and analysis method, amenable to use by commercial laboratories for the detection and quantification of both cannabinoids and terpenoids. Through analysis of developing flowers on plants, we can identify sources of variability of floral metabolites due to flower maturity and position on the plant. The terpenoid composition varied by accession and was used to cluster cannabis strains into specific types. Inclusion of terpenoids with cannabinoids in the analysis of medical cannabis should be encouraged, as both of these classes of compounds could play a role in the beneficial medical effects of different cannabis strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.