Evidence map›Paper›PMID 30036178›Full record

ArticleBlood transfusion = Trasfusione del sangue2018

Prevalence, incidence and residual risk of transfusion-transmitted hepatitis C virus and human immunodeficiency virus after the implementation of nucleic acid testing in Italy: a 7-year (2009-2015) survey.

Claudio Velati, Luisa Romanò, Vanessa Piccinini, Giuseppe Marano, Liviana Catalano, Simonetta Pupella, Giuseppina Facco, Ilaria Pati, Maria Elena Tosti, Stefania Vaglio and 3 more

Abstract read
In one paragraph

Article in Blood transfusion = Trasfusione del sangue, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Claudio VelatiItalian Society of Transfusion Medicine and Immunohaematology, Rome, Italy.
Luisa RomanòDepartment of Biomedical Sciences for Health, University of Milan, Milan, Italy.
Vanessa PiccininiItalian National Blood Centre, National Institute of Health, Rome, Italy.
Giuseppe MaranoItalian National Blood Centre, National Institute of Health, Rome, Italy.
Liviana CatalanoItalian National Blood Centre, National Institute of Health, Rome, Italy.
Simonetta PupellaItalian National Blood Centre, National Institute of Health, Rome, Italy.
Giuseppina FaccoItalian National Blood Centre, National Institute of Health, Rome, Italy.
Ilaria PatiItalian National Blood Centre, National Institute of Health, Rome, Italy.
Maria Elena TostiNational Centre for Global Health, National Institute of Health, Rome, Italy.
Stefania VaglioItalian National Blood Centre, National Institute of Health, Rome, Italy.
Giuliano GrazziniItalian National Blood Centre, National Institute of Health, Rome, Italy.
Alessandro ZanettiDepartment of Biomedical Sciences for Health, University of Milan, Milan, Italy.
Giancarlo M LiumbrunoItalian National Blood Centre, National Institute of Health, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn Italy nucleic acid testing (NAT) became mandatory for hepatitis C virus (HCV) in 2002 and for human immunodeficiency virus (HIV) and hepatitis B virus in 2008. The aim of this study was to monitor the incidence and prevalence of HIV and HCV infections in Italian blood donors and the current residual risk of these infections after the introduction of NAT. MATERIALS AND

methodsThe Italian national blood surveillance system includes data from tests used to screen for transfusion-transmissible infections. During the period of this survey (2009-2015), the NAT methods used were the transcription-mediated amplification test, for individual donor testing, and polymerase chain reaction analysis, mainly for pools of six donors. Prevalence and incidence were calculated. Three published formulae were applied to estimate the residual risk (the window period ratio model and the formulae recommended by the European Medicines Agency and the World Health Organization).

resultsOverall, 12,258,587 blood donors and 21,808,352 donations were tested for HCV and HIV. The prevalence of HCV decreased from 110.3×10 DISCUSSION: HCV infection has declined over time in both first-time and repeat donors, while the data for HIV infection are stable. All three methods employed in this study showed that the residual risk of transmitting HCV or HIV through an infected blood unit is currently very low in Italy, but there are considerable differences in estimates between methods. Thus, harmonisation of these methods is advisable.

Indexed as

Blood DonorsBlood TransfusionHepacivirusHepatitis CHIV-1Nucleic Acid Amplification TechniquesAdolescentAdultAgedFemaleHIV InfectionsHumansIncidenceMaleMiddle AgedPrevalenceRNA, Viral

Identifiers

PMID30036178
PMCPMC6125236

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.