Trial reportBlood transfusion = Trasfusione del sangue2018
Cost-effectiveness analysis of ferric carboxymaltose in pre-operative haemoglobin optimisation in patients undergoing primary knee arthroplasty.
Trial report in Blood transfusion = Trasfusione del sangue, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Lack of Cost-Effectiveness of Preoperative Erythropoiesis-Stimulating Agents and/or Iron Therapy in Anaemic, Elective Surgery Patients: A Systematic Review and Updated Analysis.PharmacoEconomics · 2021Pooled it
- Platelet-rich plasma for sports-related muscle, tendon and ligament injuries: an umbrella review.Blood transfusion = Trasfusione del sangue · 2019Pooled it
- The use of platelet-rich plasma in oral surgery: a systematic review and meta-analysis.Blood transfusion = Trasfusione del sangue · 2019Pooled it
- Review
- Navigating anemia and anticoagulation in elderly patients undergoing orthopedic surgery: strategies for preventing complications and implementing treatments.Blood transfusion = Trasfusione del sangue · 2024Review
- Preoperative Intravenous Iron for Iron Deficiency is Cost-Effective Prior to Major Elective Surgery.PharmacoEconomics · 2022Article
- Perioperative blood management programme in Jehovah's witnesses undergoing total knee arthroplasty: clinical results and cost-benefit analysis.Orthopedic reviews · 2022Article
- Cost-Effectiveness and Budget Impact of Comprehensive Anemia Management, The First Pillar of Patient Blood Management, on the Turkish Healthcare System.ClinicoEconomics and outcomes research : CEOR · 2022Article
- Efficacy and Safety of Intravenous Ferric Carboxymaltose in Patients with Postoperative Anemia Following Same-Day Bilateral Total Knee Arthroplasty: A Randomized Controlled Trial.Journal of clinical medicine · 2021Article
- Screening and treating pre-operative anaemia and suboptimal iron stores in elective colorectal surgery: a cost effectiveness analysis.Anaesthesia · 2021Article
- Effectiveness of iron supplementation in the perioperative management of total knee arthroplasty: a systematic review.Knee surgery & related research · 2020Article
- Intravenous ferric carboxymaltose is effective and safe in patients with inflammatory rheumatic diseases.Blood transfusion = Trasfusione del sangue · 2020Article
- Improving the treatment of pre-operative anemia in hepato-pancreato-biliary patients: a quality improvement initiative.Patient safety in surgery · 2020Article
- Patient Blood Management: a revolutionary approach to transfusion medicine.Blood transfusion = Trasfusione del sangue · 2019Review
- Implementation of a patient blood management programme in obstetrics: let's do it!Blood transfusion = Trasfusione del sangue · 2019Article
- Iron Deficiency Anemia in Colorectal Cancer Patients: Is Preoperative Intravenous Iron Infusion Indicated? A Narrative Review of the Literature.Cancer diagnosis & prognosisReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn analytic-decision model was built to estimate the cost-effectiveness of using ferric carboxymaltose for pre-operative haemoglobin optimisation in patients with iron deficiency anaemia undergoing primary knee arthroplasty. MATERIALS AND
methodsWe simulated 20,000 patients who were randomly assigned to the haemoglobin optimisation arm or the non-optimisation control arm in a strict 1:1 ratio. The main outcomes were cost per patient transfusion avoided and red blood cell units spared. The analyses were performed from the hospital perspective with length of stay as the time horizon.
resultsIn the reference case scenario, pre-operative haemoglobin optimisation led to fewer patients being exposed to allogeneic red blood cell transfusion (2,212 vs 6,595 out of 10,000 patients) and a relevant decrease in the number of red blood cell units transfused (4.342 vs 13.336). The costs of avoiding one patient transfusion and sparing one red blood cell unit were € 831 and € 405, respectively. Increased costs in the optimisation arm were mostly associated with the outpatient day hospital visit (54%) and ferric carboxymaltose treatment (40%). DISCUSSION: In primary knee arthroplasty, pre-operative haemoglobin optimisation with intravenous ferric carboxymaltose is less expensive than other reported patient blood management modalities and must be considered in patients with iron deficiency anaemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.