Evidence map›Paper›PMID 30036072›Full record

ArticleAIDS patient care and STDs2018

HIV-Uninfected Kenyan Adolescent and Young Women Share Perspectives on Using Pre-Exposure Prophylaxis During Pregnancy.

Jillian Pintye, Kristin M Beima-Sofie, Pamela A Makabong'O, Anne Njoroge, Susan Brown Trinidad, Renee A Heffron, Jared M Baeten, Connie Celum, Daniel Matemo, John Kinuthia and 2 more

Abstract read
In one paragraph

Article in AIDS patient care and STDs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Jillian PintyeDepartment of Global Health, University of Washington, Seattle, Washington.
Kristin M Beima-SofieDepartment of Global Health, University of Washington, Seattle, Washington.
Pamela A Makabong'OPartners in Health Research and Development, Thika, Kenya.
Anne NjorogeDepartment of Global Health, University of Washington, Seattle, Washington.
Susan Brown TrinidadDepartment of Bioethics and Humanities, University of Washington, Seattle, Washington.
Renee A HeffronDepartment of Global Health, University of Washington, Seattle, Washington.
Jared M BaetenDepartment of Global Health, University of Washington, Seattle, Washington.
Connie CelumDepartment of Global Health, University of Washington, Seattle, Washington.
Daniel MatemoKenyatta National Hospital, Nairobi, Kenya.
John KinuthiaDepartment of Global Health, University of Washington, Seattle, Washington.
Maureen C KelleyNuffield Department of Population Health, The Ethox Center and Wellcome Center for Ethics and Humanities, University of Oxford, Oxford, United Kingdom.
Grace C John-StewartDepartment of Global Health, University of Washington, Seattle, Washington.
University of Washington · USKenyatta National Hospital · KEPartners for Health and Development in Africa · KEWellcome Centre for Ethics and Humanities · GB

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Kenneth Sherr · 1988 to 2026
$104.9M
VENEREAL DISEASET32AI007140 · NIAID · UNIVERSITY OF WASHINGTON · PI Julia Cook Dombrowski · 1985 to 2026
$19.4M
Optimizing Antiretroviral-Based HIV Prevention for HIV Serodiscordant CouplesR01MH095507 · NIMH · UNIVERSITY OF WASHINGTON · PI BAETEN, JARED · 2011 to 2020
$6.1M
Pediatric HIV-1 in Africa: Pathogenesis and ManagementK24HD054314 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C. · 2006 to 2016
$1.2M
Adherence to Pre-Exposure Prophylaxis for HIV Prevention in PregnancyF32NR017125 · NINR · UNIVERSITY OF WASHINGTON · PI PINTYE, JILLIAN · 2017 to 2017
$61k
NIAID NIH HHS P30 AI027757NIAID NIH HHS T32 AI007140NICHD NIH HHS K24 HD054314NIMH NIH HHS R01 MH095507NINR NIH HHS F32 NR017125Wellcome Trust 096527
6 · The paper itself

Abstract

To optimize scale-up of pre-exposure prophylaxis (PrEP) for pregnant women at risk of HIV in high HIV burden settings, implementation strategies must be developed that account for perceptions of PrEP in this unique population. Semistructured focus group discussions were conducted with 68 HIV-uninfected Kenyan pregnant and postpartum women without prior PrEP knowledge or experience. A qualitative descriptive analysis was performed, using a constant comparison approach, to identify key themes related to the values and rationale impacting potential PrEP use in pregnancy. Median age was 19.5 years and participants were either pregnant or had 1-2 children. Almost all (96%) were married or had a steady partner. Women felt pregnancy was a time of high HIV risk because they desired sex less frequently, which may lead their partners to have outside partnerships. This made PrEP an attractive HIV prevention option for themselves and their infants. Although women believed male partner behaviors influenced their HIV risk, many women perceived that male partners would react negatively, including becoming physically violent, if they discovered that women used PrEP. Clinicians were identified as potential facilitators of PrEP use who could explain PrEP to male partners on behalf of pregnant women. Women said that community-level stigma against HIV and potential for conflating PrEP with antiretroviral therapy (ART) would necessitate that PrEP use be discreet. Our results indicate the importance of addressing risk perception of women, concerns of male partners, HIV stigma, and benefits of PrEP for HIV prevention as programs are developed for pregnant women.

Indexed as

Black PeoplePregnant PeopleAdolescentAdultAnti-HIV AgentsFemaleHIV InfectionsHIV SeronegativityHumansKenyaMalePre-Exposure ProphylaxisPregnancySexual PartnersSocial StigmaYoung AdultAnti-HIV AgentsAfricaobstetrics/gynecologyPrEPprevention of mother to child transmission/vertical transmissionprevention of sexual transmissionqualitative datawomen

Identifiers

PMID30036072
PMCPMC6300042
OpenAlexW2883039839

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.