Evidence map›Paper›PMID 30036031›Full record

ArticleACS applied materials & interfaces2018

Erythrocyte-Derived Theranostic Nanoplatforms for Near Infrared Fluorescence Imaging and Photodestruction of Tumors.

Joshua M Burns, Raviraj Vankayala, Jenny T Mac, Bahman Anvari

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 40 citations in OpenAlex.

  1. Effects of OACS applied bio materials · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Hypothermal opto-thermophoretic tweezers.Nature communications · 2023
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Cell Membrane-Cloaked Nanotherapeutics for Targeted Drug Delivery.International journal of molecular sciences · 2022
    Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. RBC-Derived Optical Nanoparticles Remain Stable After a Freeze-Thaw Cycle.Langmuir : the ACS journal of surfaces and colloids · 2020
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Joshua M BurnsDepartment of Bioengineering , University of California, Riverside , 900 University Avenue , Riverside , California 92521 , United States.
Raviraj VankayalaDepartment of Bioengineering , University of California, Riverside , 900 University Avenue , Riverside , California 92521 , United States.
Jenny T MacDepartment of Biochemistry , University of California, Riverside , 900 University Avenue , Riverside , California 92521 , United States.
Bahman AnvariDepartment of Bioengineering , University of California, Riverside , 900 University Avenue , Riverside , California 92521 , United States.ORCID http://orcid.org/0000-0002-2511-5854
University of California, Riverside · US

Funding

Erythrocyte-derived optical nano-probes for image-guided identification of tumor margins and cancer resectionR43CA210715 · NCI · RADOPTICS, LLC · PI VANKAYALA, RAVIRAJ · 2017 to 2017
$262k
NCI NIH HHS R43 CA210715
6 · The paper itself

Abstract

Nanoparticles activated by near-infrared (NIR) excitation provide a capability for optical imaging and photodestruction of tumors. We have engineered optical nanoconstructs derived from erythrocytes, which are doped with the FDA-approved NIR dye, indocyanine green (ICG). We refer to these constructs as NIR erythrocyte-mimicking transducers (NETs). Herein, we investigate the phototheranostic capabilities of NETs for fluorescence imaging and photodestruction of SKBR3 breast cancer cells and subcutaneous xenograft tumors in mice. Our cellular studies demonstrate that NETs are internalized by these cancer cells and localized to their lysosomes. As evidenced by NIR fluorescence imaging and in vivo laser irradiation studies, NETs remain available within tumors at 24 h postintravenous injection. In response to continuous wave 808 nm laser irradiation at intensity of 680 mW/cm

Indexed as

ErythrocytesAnimalsIndocyanine GreenMiceNanoparticlesNeoplasmsTheranostic NanomedicineIndocyanine Greenapoptosisindocyanine greenlysosomesphotodynamic therapyphotothermal therapyred blood cells

Identifiers

PMID30036031
PMCPMC6526021
OpenAlexW2883955846

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.