Evidence map›Paper›PMID 30035850›Full record

ArticleThe FEBS journal2018

Ca

Perry Caviness, Ryan Bauer, Keisuke Tanaka, Katarzyna Janowska, Jeffrey Randall Roeser, Dawn Harter, Jes Sanders, Christopher Ruth, Osamu Matsushita, Joshua Sakon

Open access · bronzeAbstract read
In one paragraph

Article in The FEBS journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Perry CavinessDepartment of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR, USA.
Ryan BauerDepartment of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR, USA.
Keisuke TanakaNippi Research Institute of Biomatrix, Toride, Ibaraki, Japan.
Katarzyna JanowskaDepartment of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR, USA.
Jeffrey Randall RoeserDepartment of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR, USA.
Dawn HarterDepartment of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR, USA.
Jes SandersDepartment of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR, USA.
Christopher RuthDepartment of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR, USA.
Osamu MatsushitaDepartment of Bacteriology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.
Joshua SakonDepartment of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR, USA.
University of Arkansas at Fayetteville · USJapan Institute of Leather Research · JPOkayama University · JP

Funding

Understanding Hesitant AdoptersP20GM103429 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Lawrence E Cornett, JERRY WARE · 2012 to 2026
$60.9M
VIRULENCE MECHANISMS IN ESCHERICHIA COLIP20RR016460 · NCRR · UNIV OF ARKANSAS FOR MED SCIS · PI HENSLEY, LORI · 2001 to 2011
$33.1M
User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS · 2017 to 2026
$28.6M
Center for Protein Structure and FunctionP30GM103450 · NIGMS · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI MILLETT, FRANCIS S · 2012 to 2014
$3.2M
NCRR NIH HHS P20 RR016460NIGMS NIH HHS P20 GM103429NIGMS NIH HHS P30 GM103450NIGMS NIH HHS P30 GM124169
6 · The paper itself

Abstract

To penetrate host tissues, histotoxic clostridia secrete virulence factors including enzymes to hydrolyze extracellular matrix. Clostridium histolyticum, recently renamed as Hathewaya histolytica, produces two classes of collagenase (ColG and ColH). The high-speed AFM study showed that ColG collagenase moves unidirectionally to plane collagen fibril and rebundles fibril when stalled . The structural explanation of the roles for the tandem collagen-binding segment (CBDs) is illuminated by its calcium-bound crystal structure at 1.9 Å resolution (R ACCESSION CODES: The full atomic coordinates of the tandem CBD and its corresponding structure factor amplitudes have been deposited in the Protein Data Bank (PDB accession code 5IKU). Small-angle X-ray scattering data and corresponding ab initio models have been submitted to the Small Angle Scattering Biological Data Bank (SASBDB). Accession codes CL2, collagenase module 2, CN2, CP2 are assigned to envelopes for tandem CBD at -log[Ca

Indexed as

Amino Acid SequenceCalciumCollagenCollagenasesCrystallography, X-RayHathewaya histolyticaModels, MolecularPhylogenyProtein BindingProtein ConformationSequence HomologySignal TransductionCalciumCollagenCollagenasesbacterial collagenasecrystal structuregene duplicationprocessive proteasesite-directed drug delivery system

Identifiers

PMID30035850
PMCPMC6126967
OpenAlexW2883349899

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.