Evidence map›Paper›PMID 30035325›Full record

Trial reportInternational journal of geriatric psychiatry2018

Resilience predicts remission in antidepressant treatment of geriatric depression.

Kelsey T Laird, Helen Lavretsky, Natalie St Cyr, Prabha Siddarth

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in International journal of geriatric psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

  1. A Randomized Controlled Trial of Tai Chi Chih or Health Education for Geriatric Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022
    Trial
  2. A Randomized Double-Blind Placebo-Controlled Trial of Combined Escitalopram and Memantine for Older Adults With Major Depression and Subjective Memory Complaints.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2020
    Trial
  3. Article
  4. [Frailty at the interface of resilience and intrinsic capacity].Innere Medizin (Heidelberg, Germany) · 2025
    Review
  5. Resilience in Older People: A Concept Analysis.Healthcare (Basel, Switzerland) · 2023
    Article
  6. Article
  7. Review
  8. Observational
  9. Article
  10. Review
  11. Neurocognitive Correlates of Resilience in Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kelsey T LairdDepartment of Psychiatry, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA, USA.ORCID 0000-0002-3194-2522
Helen LavretskyDepartment of Psychiatry, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA, USA.
Natalie St CyrDepartment of Psychiatry, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA, USA.
Prabha SiddarthDepartment of Psychiatry, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA, USA.
Center for Neurosciences · US

Funding

Methylphenidate Use to Improve Outcomes in Geriatric DepressionR01MH077650 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAVRETSKY, HELEN · 2008 to 2012
$1.8M
Mentoring and Research in Translational Science of Integrative MedicineK24AT009198 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Helen Lavretsky · 2016 to 2026
$1.4M
Neurobiological Mechanisms of Treatment Response in Geriatric DepressionK24MH086481 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAVRETSKY, HELEN · 2010 to 2014
$906k
NCCIH NIH HHS K24 AT009198NIMH NIH HHS K24 MH086481NIMH NIH HHS R01 MH077650
6 · The paper itself

Abstract

objectivesWith the world population rapidly aging, it is increasingly important to identify sociodemographic, cognitive, and clinical features that predict poor outcome in geriatric depression. Self-report measures of resilience-ie, the ability to adapt and thrive in the face of adversity-may identify those depressed older adults with more favorable prognoses.

methodsWe investigated the utility of baseline variables including 4 factors of resilience (grit, active coping self-efficacy, accommodative coping self-efficacy, and spirituality) for predicting treatment response and remission in a 16-week randomized controlled trial of methylphenidate, citalopram, or their combination in 143 adults over the age of 60 with MDD.

resultsFinal logistic regression models revealed that greater total baseline resilience (Wald χ

conclusionsSelf-reported resilience may predict greater responsivity to antidepressant medication in older adults with MDD. Future research should investigate the potential for resilience training-and in particular, interventions designed to increase accommodative coping-to promote sustained remission of geriatric depression.

Indexed as

Depressive DisorderGeriatric PsychiatryResilience, PsychologicalAdaptation, PsychologicalAgedAged, 80 and overAntidepressive AgentsCitalopramFemaleHumansLogistic ModelsMaleMethylphenidateMiddle AgedSelf EfficacyTreatment OutcomeAntidepressive AgentsCitalopramMethylphenidateacceptanceelderlygeriatricsindividual differencesmoderatorproblem-solving therapypsychiatryremitresilientSSRI

Identifiers

PMID30035325
PMCPMC6246780
OpenAlexW2883408198

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.