ArticleJournal of orthopaedic translation2017
Bacterial inhibition potential of quaternised chitosan-coated VICRYL absorbable suture: An
Article in Journal of orthopaedic translation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Absorbable versus non-absorbable suture in percutaneous laparoscopic inguinal hernia repair in children: a systematic review and meta-analysis.Pediatric surgery international · 2026Pooled it
- Investigation of antibiotic release from amoxicillin- and clindamycin-impregnated silk and Vicryl suture materials: an in vitro study.BMC oral health · 2026Article
- An in vitro study on the efficacy of nanoparticles and nanocomposites as coating materials on surgical sutures.Scientific reports · 2025Article
- Graphene oxide/gallium nanoderivative as a multifunctional modulator of osteoblastogenesis and osteoclastogenesis for the synergistic therapy of implant-related bone infection.Bioactive materials · 2023Article
- Recent advances in the medical applications of hemostatic materials.Theranostics · 2023Review
- Biomaterial-assisted tumor therapy: A brief review of hydroxyapatite nanoparticles and its composites used in bone tumors therapy.Frontiers in bioengineering and biotechnology · 2023Review
- Review
- Biomedical Applications of Quaternized Chitosan.Polymers · 2021Review
- A 3D-bioprinted scaffold with doxycycline-controlled BMP2-expressing cells for inducing bone regeneration and inhibiting bacterial infection.Bioactive materials · 2021Article
- Chitosan-Coated Surgical Sutures Prevent Adherence and Biofilms of Mixed Microbial Communities.Current microbiology · 2021Article
- Bacterial Colonization on Different Suture Materials Used in Oral Implantology: A Randomized Clinical Trial.Frontiers in dentistry · 2021Article
- Graphene Oxide/Copper Nanoderivatives-Modified Chitosan/Hyaluronic Acid Dressings for Facilitating Wound Healing in Infected Full-Thickness Skin Defects.International journal of nanomedicine · 2020Article
- Surface treatment strategies to combat implant-related infection from the beginning.Journal of orthopaedic translation · 2019Review
- Article
- Quaternized chitosan promotes the antiproliferative effect of vemurafenib in melanoma cells by increasing cell permeability.OncoTargets and therapy · 2018Article
- Preferential Colonization of Osteoblasts Over Co-cultured Bacteria on a Bifunctional Biomaterial Surface.Frontiers in microbiology · 2018Article
- Article
- A comparative assessment of antibacterial properties of neem oil coated sutures: AnJournal of Indian Society of PeriodontologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectiveAs a widely used absorbable suture with antibacterial property, triclosan- coated polyglactin suture (Vicryl Plus) has been extensively utilized to reduce the occurrence rate of surgical site infections (SSIs) in orthopaedic surgery. However, the potential toxicity and side-effects of triclosan raised increasing concerns about its biological safety. This study aimed to investigate the antimicrobial activity and biocompatibility of quaternised chitosan-coated Vicryl suture (HV) both
methodsIn this study, a modified chitosan derivate, (hydroxypropyltrimethyl ammonium chloride chitosan, HACC), was coated over the surface of the absorbable Vicryl suture. Two standard bacteria strains,
resultsWe found that HACC-coated Vicryl suture (HV) exhibited significant anti-bacterial effects on the two tested strains. The bacterial attachment and biofilm formation on the surface of the HV sutures were found to be comparable to that of Vicryl Plus sutures (VP). Moreover, all the four tested sutures presented good cytocompatibility with human skin-derived fibroblasts cells. Histology and immunohistochemistry results indicated that the infections and inflammations were significantly inhibited around the HV and VP sutures.
conclusionIn general, the present study demonstrated that the quaternised chitosan coating is a flexible and cost-effective alternative strategy to prevent the suture related surgical site infections in orthopaedic practices.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.