ArticleJournal of orthopaedic translation2016
The effect of hydrogen gas evolution of magnesium implant on the postimplantation mortality of rats.
Article in Journal of orthopaedic translation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed.
- Hydrogen releasing biomaterials for bone regeneration: mechanisms, design strategies, and applications.Bioactive materials · 2027Review
- A high-toughness, rare-earth-free magnesium alloy with excellent biocompatibility profile: Integrated in vitro and in vivo characterization.Materials today. Bio · 2026Article
- Biophysical signal-driven scaffold design for stem cell-guided osteochondral regeneration.Bioactive materials · 2026Review
- Micro/nanorobotics for sepsis diagnosis and therapy: a frontier in precision medicine.Theranostics · 2026Review
- Magnesium Bioabsorbable vs Titanium Screws in Hallux Valgus Surgery: A Prospective, Randomized Medium-term Trial.Foot & ankle orthopaedics · 2026Article
- Biomaterials in personalized drug delivery: innovations, challenges, and future directions.PeerJ · 2026Review
- Frequency-Controlled AC-MAO Coatings with Ca, P, and Se on Magnesium: Toward Tailored Surfaces for Biodegradable Implants.Materials (Basel, Switzerland) · 2025Article
- Magnesium-containing implants enhance bone healing: A mechanobiological perspective.Mechanobiology in medicine · 2025Review
- Experimental investigation on enhancing the mechanical properties of biodegradable Zn-3Mg alloys reinforced with snail-shell particulates via powder metallurgy.Journal of materials science. Materials in medicine · 2025Article
- Systematic Study of TiC Nanoparticle Effects on the Fatigue Behavior of Zn and Zn Alloys.Journal of alloys and compounds · 2025Article
- Biodegradable Metal-Based Stents: Advances, Challenges, and Prospects.Journal of functional biomaterials · 2025Review
- Strontium-Zinc conversion coating on magnesium plates for resorbable tack screws in guided bone regeneration: Characterization and biocompatibility evaluation.Journal of clinical and experimental dentistry · 2025Article
- Biomechanical stability of magnesium plate and screw fixation systems in LeFort I osteotomy: a three-dimensional finite element analysis.Maxillofacial plastic and reconstructive surgery · 2024Article
- In Vivo Study of Organ and Tissue Stability According to the Types of Bioresorbable Bone Screws.Materials (Basel, Switzerland) · 2024Article
- An overview of magnesium-based implants in orthopaedics and a prospect of its application in spine fusion.Bioactive materials · 2024Review
- Challenges and Pitfalls of Research Designs Involving Magnesium-Based Biomaterials: An Overview.International journal of molecular sciences · 2024Review
- Magnesium implantation as a continuous hydrogen production generator for the treatment of myocardial infarction in rats.Scientific reports · 2024Article
- Prospective evaluation of ultrasound features of magnesium-based bioabsorbable screw resorption in pediatric fractures.European radiology · 2024Article
- The Biological Effects of Magnesium-Based Implants on the Skeleton and Their Clinical Implications in Orthopedic Trauma Surgery.Biomaterials research · 2024Review
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectiveHydrogen gas cavity is formed during
methodsIn this study, we investigated the effect of hydrogen gas evolution on the mortality of rats and analysed the whole body capacity to relieve the gas. Porous pure-magnesium implants were implanted in the femoral bone defect of adult Sprague-Dawley rats up to 18 days, and their survival rate was calculated while the gas cavity size was measured, and its effect was analysed with support of radiographic and blood analysis.
resultsThe gas cavity was rapidly formed surrounding the implantation site and obviously decreased the rats' survival rate. The gas was observed to swell the surrounding implantation site by filling the loose compartments and then dispersing subcutaneously to other areas.
conclusionThe rat's whole body capacity was unable to tolerate the rapid and persistent hydrogen gas cavity formation as shown by high postimplantation mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.