ArticleJournal of orthopaedic translation2015
Postmenopausal Chinese women show accelerated lumbar disc degeneration compared with Chinese men.
Article in Journal of orthopaedic translation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The trial behind it
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Who cites it
38 citing papers in PubMed, 53 citations in OpenAlex.
- Detrimental Effect of Low-Magnitude High-Frequency Vibration in an Ex Vivo Model of Intervertebral Disc Degeneration Despite Estrogen Treatment.JOR spine · 2026Article
- Interaction of Dietary Patterns and Physical Activity with Low Back Pain in Pre- to Post-Menopause: A Cross-Sectional Study.Journal of health, population, and nutrition · 2026Article
- Impact of Menopause and Associated Hormonal Changes on Spine Health in Older Females: A Review.Cells · 2026Review
- Article
- Sex difference in musculoskeletal disabilities among Korean fishers: a cross-sectional study.Annals of occupational and environmental medicine · 2025Article
- Review
- Hounsfield unit correlates with intervertebral disc degeneration in premenopausal and menopausal women: a radiological study.Journal of orthopaedic surgery and research · 2025Article
- Global, regional, and national burden of low back pain in postmenopausal women from 1990 to 2021: a comprehensive analysis using data from the Global Burden of Disease Study 2021.Frontiers in endocrinology · 2025Article
- Editorial: Women in science: musculoskeletal pain.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- 17β-estradiol maintains extracellular matrix homeostasis of nucleus pulposus cells by activating p70 S6K1 signaling pathway.Frontiers in cell and developmental biology · 2025Article
- Development of prediction model for risks of musculoskeletal chronic lumbopelvic pain in Indian women.Scientific reports · 2024Article
- Collagen integrity of the annulus fibrosus in degenerative disc disease individuals quantified with collagen hybridizing peptide.JOR spine · 2024Article
- Risk Factors for Surgical Treatment of Lumbar Degenerative Disc Disease in Middle-aged and Older Women: A Prospective Case-Control Study of 2370 Subjects.Orthopaedic surgery · 2024Article
- Sex differences in the biomechanical and biochemical responses of caudal rat intervertebral discs to injury.JOR spine · 2023Article
- Article
- Factors Predisposing to The Formation of Degenerative Spondylolisthesis-A Narrative Review.Medicina (Kaunas, Lithuania) · 2023Review
- Molecular Basic of Pharmacotherapy of Cytokine Imbalance as a Component of Intervertebral Disc Degeneration Treatment.International journal of molecular sciences · 2023Review
- Oestrogen and Vibration Improve Intervertebral Disc Cell Viability and Decrease Catabolism in Bovine Organ Cultures.International journal of molecular sciences · 2023Article
- A Brief Overview: Sex Differences in Prevalent Chronic Musculoskeletal Conditions.International journal of environmental research and public health · 2023Article
- Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivePostmenopausal women may have accelerated disc degeneration due to relative oestrogen deficiency. Two new studies supporting this concept were carried out.
methodsStudy I: The data were from the Osteoporotic Fractures in Men (Hong Kong) and Women (Hong Kong) studies. Both were population-based studies on bone health for elderly Chinese men and women (age ≥ 65 years,
resultsStudy I: Elderly women had a higher disc space narrowing score than elderly men, and the slope of the plot was steeper for females than for males. When the plots were extrapolated to younger age, they intersected at 59.67 years. Study II: An age-related reduction of T2 value in the nucleus pulposus was demonstrated, which was faster in females than in males. Although females tended to have initial higher T2 value before 50 years, this trend was reversed in elderly persons, with an intersection at 52.4 years.
conclusionPostmenopausal Chinese women show accelerated lumbar disc degeneration compared with Chinese men.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.