ArticleJournal of orthopaedic translation2015
Article in Journal of orthopaedic translation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Current advances in animal model of meniscal injury: From meniscal injury to osteoarthritis.Journal of orthopaedic translation · 2025Review
- Cartilage morphometry and magnetic susceptibility measurement for knee osteoarthritis with automatic cartilage segmentation.Quantitative imaging in medicine and surgery · 2023Article
- A musculoskeletal finite element model of rat knee joint for evaluating cartilage biomechanics during gait.PLoS computational biology · 2022Article
- New imaging tools for mouse models of osteoarthritis.GeroScience · 2022Review
- Three-dimensional finite-element analysis of aggravating medial meniscus tears on knee osteoarthritis.Journal of orthopaedic translation · 2020Article
- Image interpolation improves the zonal analysis of cartilage T2 relaxation in MRI.Quantitative imaging in medicine and surgery · 2017Article
- Topographical and depth-dependent glycosaminoglycan concentration in canine medial tibial cartilage 3 weeks after anterior cruciate ligament transection surgery-a microscopic imaging study.Quantitative imaging in medicine and surgery · 2016Article
- Animal models of osteoarthritis: classification, update, and measurement of outcomes.Journal of orthopaedic surgery and research · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectiveIn a rat meniscal tear model of osteoarthritis (OA), a full-thickness cut in the medial meniscus leads to joint instability and progressive development of knee OA. This study evaluated
methodsA left knee meniscal tear procedure was carried out on 10 rats, and sham surgery was performed on five rats. The joints were MRI scanned 44 days after surgery at 4.7 Tesla. A 3D data set was acquired using a 3D spoiled gradient echo sequence at a resolution of 59 × 117 × 234 μm
resultsThe medial meniscus tear was clearly visible with MRI. Cartilage damage was seen in all animals, with varying degrees of severities, which included a decrease of cartilage thickness and loss of cartilage in some areas, and focal neocartilage proliferation at the joint margin. Damage to the subchondral bone included local osteosclerosis, deformed tibia cortex surface, and osteophytes. The damage to the cartilage and bone was most extensive on the weight-bearing region of the medial tibial plateau. No apparent subchondral bone damage was observed in the epiphysis of the femur. In five animals, single or multiple high MR signal areas were seen within the epiphysis of the tibia, consistent with epiphyseal cyst formation. The knee interarticular space on the media side was slightly increased in two animals. Mild femur-tibia axis misalignment was seen in one animal. Changes seen on MRI were consistent with histopathological changes.
conclusionMRI offers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.