ArticleNeuroImage. Clinical2018
Sexually dimorphic structural abnormalities in major connections of the medial forebrain bundle in alcoholism.
Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Alcohol Cues Elicit Differences in Brain Activation Patterns of Abstinent Men and Women with Alcohol Use Disorders.Neuropsychiatric disease and treatment · 2026Article
- Connectomics modeling of regional networks of white-matter fractional anisotropy to predict the severity of young adult drinking.Quantitative imaging in medicine and surgery · 2025Article
- Sex-based Influences on White Matter Tract Integrity in Alcohol Use Disorder: a Systematic Review.Current addiction reports · 2025Article
- Sex and sobriety: Human brain structure and function in AUD abstinence.Alcohol (Fayetteville, N.Y.) · 2024Review
- Bed nucleus of the stria terminalis network responses to unpredictable threat in early alcohol abstinence.Alcohol, clinical & experimental research · 2024Article
- Investigating the structural network underlying brain-immune interactions using combined histopathology and neuroimaging: a critical review for its relevance in acute and long COVID-19.Frontiers in psychiatry · 2024Review
- Hypothesizing in the Face of the Opioid Crisis Coupling Genetic Addiction Risk Severity (GARS) Testing with Electrotherapeutic Nonopioid Modalities Such as H-Wave Could Attenuate Both Pain and Hedonic Addictive Behaviors.International journal of environmental research and public health · 2022Article
- Evaluating effects of sex and age on white matter microstructural alterations in alcohol use disorder: A diffusion tensor imaging study.Alcoholism, clinical and experimental research · 2021Article
- Brain, behavioral, affective, and sex correlates of recovery from alcohol use disorders.Alcoholism, clinical and experimental research · 2021Article
- The role of the orbitofrontal cortex and the nucleus accumbens for craving in alcohol use disorder.Translational psychiatry · 2021Article
- Alterations in connectivity of the bed nucleus of the stria terminalis during early abstinence in individuals with alcohol use disorder.Alcoholism, clinical and experimental research · 2021Article
- Microstructural alterations in medial forebrain bundle are associated with interindividual pain sensitivity.Human brain mapping · 2021Article
- Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years.Journal of neuroscience research · 2021Review
- Brain responsivity to emotional faces differs in men and women with and without a history of alcohol use disorder.PloS one · 2021Article
- Alcohol's Unique Effects on Cognition in Women: A 2020 (Re)view to Envision Future Research and Treatment.Alcohol research : current reviews · 2020Review
- Hippocampal subfield volumes in abstinent men and women with a history of alcohol use disorder.PloS one · 2020Article
- Americas' opioid/psychostimulant epidemic would benefit from general population early identification of genetic addiction risk especially in children of alcoholics (COAs).Journal of systems and integrative neuroscience · 2019Article
- Article
- Increased structural connectivity of the medial forebrain bundle in schizophrenia spectrum disorders is associated with delusions of paranoid threat and grandiosity.NeuroImage. Clinical · 2019Article
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Authors and funding
9 authors.
Funding
Abstract
Background: The mesocorticolimbic system is particularly susceptible to the effects of chronic alcoholism. Disruption of this system has been linked to drug seeking and the development of Reward Deficiency Syndrome, a neurobiological framework for describing the development and relapsing patterns of addictions. In this study, we evaluated the association of alcoholism and sex with major connections of the medial forebrain bundle (MFB), a prominent mesocorticolimbic fiber pathway connecting the ventral tegmental area with the basal forebrain. Given sex differences in clinical consequences of alcohol consumption, we hypothesized that alcoholic men and women would differ in structural abnormalities of the MFB. Methods: Diffusion magnetic resonance imaging (dMRI) data were acquired from 30 abstinent long-term alcoholic individuals (ALC; 9 men) and 25 non-alcoholic controls (NC; 8 men). Major connections of the MFB were extracted using multi-tensor tractography. We compared groups on MFB volume, fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD), with hemisphere and sex as independent variables. We also evaluated associations between abnormal structural measures and drinking measures. Results: Analyses revealed significant group-by-sex interactions for FA and RD: while ALC men had lower FA and higher RD compared to NC men, ALC women had higher FA and lower RD compared to NC women. We also detected a significant negative association between FA and number of daily drinks in ALC women. Conclusion: Alcoholism is associated with sexually dimorphic structural abnormalities in the MFB. The results expand upon other findings of differences in brain reward circuitry of alcoholic men and women.
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