Evidence map›Paper›PMID 30034950›Full record

ArticleTranslational vision science & technology2018

Inherited Retinal Degenerations: Current Landscape and Knowledge Gaps.

Jacque L Duncan, Eric A Pierce, Amy M Laster, Stephen P Daiger, David G Birch, John D Ash, Alessandro Iannaccone, John G Flannery, José A Sahel, Donald J Zack and 2 more

Registry-linked trialAbstract read
In one paragraph

Article in Translational vision science & technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06242379 (Safety and Efficacy Evaluation of Intravitreal Injection of GMP-compliant Bone Marrow Mesenchymal Stem Cell-derived Small Extracellular Vesicles in Patients With Retinitis Pigmentosa), which is not on this map. Cited by 168 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
168citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06242379 phase1 / phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Safety and Efficacy Evaluation of Intravitreal Injection of GMP-compliant Bone Marrow Mesenchymal Stem Cell-derived Small Extracellular Vesicles in Patients With Retinitis Pigmentosa

TypeinterventionalSponsorMahidol UniversityRan2024 to 2027Enrolled15ConditionsRetinitis PigmentosaArmsGMP compliant-BM-MSC derived sEVs
3 · Its place in the literature

Who cites it

168 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Illuminating retinoid flux in the neurosensory retina.The Journal of clinical investigation · 2026
    Review
  14. Artificial intelligence applications in inherited retinal dystrophies.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

108 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jacque L DuncanDepartment of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA.
Eric A PierceOcular Genomics Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.
Amy M LasterFoundation Fighting Blindness, Columbia, MD, USA.
Stephen P DaigerHuman Genetics Center, School of Public Health, and Ruiz Department of Ophthalmology and Visual Science, The University of Texas Health Science Center, Houston, TX, USA.
David G BirchRose-Silverthorne Retinal Degenerations Laboratory, Retina Foundation of the Southwest, Dallas, TX, USA.
John D AshDepartment of Ophthalmology, University of Florida, Gainesville, FL, USA.
Alessandro IannacconeCenter for Retinal Degenerations and Ophthalmic Genetic Diseases, Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA.
John G FlanneryVision Science, the Helen Wills Neuroscience Institute, the Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
José A SahelDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Donald J ZackDepartments of Ophthalmology, Neuroscience, Molecular Biology and Genetics, and Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Marco A ZarbinInstitute of Ophthalmology and Visual Science, Rutgers-New Jersey Medical School, Rutgers University, Newark, NJ, USA.
and the Foundation Fighting Blindness Scientific Advisory Board

Funding

DNA LINKAGE STUDIES OF DEGENERATIVE RETINAL DISEASESR01EY007142 · NEI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DAIGER, STEPHEN P · 1989 to 2017
$4.1M
Cytokine Regulation of Photoreceptor Gene ExpressionR01EY016459 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ASH, JOHN D · 2006 to 2017
$4.0M
NEI NIH HHS R01 EY007142NEI NIH HHS R01 EY016459
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID30034950
PMCPMC6052953

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.