ArticleJournal of thoracic disease2018
An acoustic method for systematic ventricular assist device thrombus evaluation with a novel artificial thrombus model.
Article in Journal of thoracic disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 23 citations in OpenAlex.
- Analysis of aortic valve prostheses using advanced cardiovascular imaging-a patient-specific reversed translational approach.Scientific reports · 2026Article
- Machine Learning Prediction of Left Ventricular Assist Device Thrombosis from Acoustic Harmonic Power.Bioengineering (Basel, Switzerland) · 2025Article
- Detecting Suspected Pump Thrombosis in Left Ventricular Assist Devices via Acoustic Analysis.IEEE journal of biomedical and health informatics · 2020Article
- Acoustic Signatures of Left Ventricular Assist Device Thrombosis.Journal of engineering and science in medical diagnostics and therapy · 2019Article
- The evolution of mechanical circulatory support (MCS): a new wave of developments in MCS and heart failure treatment.Journal of thoracic disease · 2018Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPump thrombosis (PT) is still one of the major adverse events in patients supported with left ventricular assist devices. Nowadays, thrombus detection relies on clinical parameters like reoccurring heart failure symptoms, on changes in pump power consumption, and on laboratory parameters such as increased LDH and hemolysis. Once detected PT is most often persistent and refractory to medical therapy. We therefore designed a novel, non-invasive acoustic method for early pump thrombus detection in an
methodsThe study was performed
resultsMeasurements with thrombi on the tilted pad showed an increased number of frequency peaks with all thrombus sizes compared to baseline measurements without any thrombus (baseline: 32.7±7.4; 0.5 mg: 45.3±10.4 up to 5 mg: 80.4±5.5). Power consumption was relevantly elevated in 5mg thrombus measurement only (6.3±1.29 W compared to 4.9±0.14 W at baseline). Measurements with thrombi in the primary and secondary showed no relevant alteration in power consumption and frequency peak count.
conclusionsWe present an acoustic method that detects pump thrombi located on the tilted pad of the HVAD rotor requiring ten times less mass compared to thrombi detected by power consumption alterations used in current detection algorithms. Assuming that pump thrombi are growing over several days, the presented method may detect PT much earlier thereby increasing efficacy of medical therapy and helping to avoid pump exchange.
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