ArticleCanadian journal of kidney health and disease2018
Thiazide Diuretic Dose and Risk of Kidney Stones in Older Adults: A Retrospective Cohort Study.
Article in Canadian journal of kidney health and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Low-Dose Indapamide vs. Hydrochlorothiazide in Idiopathic Hypercalciuria: A Randomized Prospective Trial.Journal of clinical medicine · 2025Article
- Kidney Stone Prevention.Advances in nutrition (Bethesda, Md.) · 2023Review
- Article
- Molecular mechanisms altering tubular calcium reabsorption.Pediatric nephrology (Berlin, Germany) · 2022Review
- Thiazide and thiazide-like diuretics in nephrolithiasis.Jornal brasileiro de nefrologiaArticle
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThiazide diuretics are commonly prescribed to prevent kidney stones. However, it is unclear whether higher doses confer greater benefit.
objectiveTo determine whether lower doses of thiazide diuretics confer a similar protective effect against kidney stone events as higher doses.
designPopulation-based cohort study.
settingLinked health administrative databases in Ontario, Canada. PATIENTS: Older adults newly prescribed a thiazide diuretic between 2003 and 2014 were separated into 2 groups based on daily dose: low dose (⩽12.5 mg hydrochlorothiazide/chlorthalidone, or ⩽1.25 mg indapamide) or high dose. MEASUREMENTS: The primary outcome was time to a kidney stone event, using diagnosis and procedure codes. A secondary outcome was kidney stone surgery.
methodsAn association between thiazide diuretic dose and a kidney stone event was estimated using Cox proportional hazards regression.
resultsA total of 536 of 105 239 patients (0.51%) experienced a kidney stone event. We did not detect a difference in kidney stone risk in the high-dose relative to the low-dose group (adjusted hazard ratio, 1.10; 95% confidence interval, 0.93-1.31). Results were similar when analysis was restricted to the more specific outcome of kidney stone surgery. Neither a history of prior kidney stones nor the type of thiazide diuretic modified the effect of diuretic dose on outcome. LIMITATIONS: Patients were >65 years old and we were unable to adjust for some potential confounders such as dietary factors.
conclusionsLower dose thiazide diuretics appear to confer a similar protective effect as higher dose thiazides against the development of kidney stones.
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