ArticleChemical science2016
DNA-mediated cell surface engineering for multiplexed glycan profiling using MALDI-TOF mass spectrometry.
Article in Chemical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Screening of glycan biomarkers for early detection of colorectal cancer based on novel isotope labeling relative quantitative method.Journal of pharmaceutical analysis · 2025Article
- Review
- Glycosphingolipids in Cardiovascular Disease: Insights from Molecular Mechanisms and Heart Failure Models.Biomolecules · 2024Review
- Sensitive Method To Analyze Cell Surface GPI-Anchored Proteins Using DNA Hybridization Chain Reaction-Mediated Signal Amplification.Analytical chemistry · 2024Article
- In Situ Glycan Analysis and Editing in Living Systems.JACS Au · 2024Review
- Concanavalin A inhibits human liver cancer cell migration by regulating F-actin redistribution and assembly via MAPK signaling pathway.Oncology letters · 2022Article
- From Bench to Cell: A Roadmap for Assessing the Bioorthogonal "Click" Reactivity of Magnetic Nanoparticles for Cell Surface Engineering.Bioconjugate chemistry · 2022Article
- Engineering living cells with cucurbit[7]uril-based supramolecular polymer chemistry: from cell surface engineering to manipulation of subcellular organelles.Chemical science · 2022Article
- Proteomic Distributions in CD34+ Microvascular Niche Patterns of Glioblastoma.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2022Article
- A Versatile Solid-Phase Approach to the Synthesis of Oligonucleotide Conjugates with Biodegradable Hydrazone Linker.Molecules (Basel, Switzerland) · 2021Article
- Laser cleavable probes forChemical science · 2019Article
- An open-space microfluidic chip with fluid walls for online detection of VEGFChemical science · 2019Article
- Nanoparticle-based surface assisted laser desorption ionization mass spectrometry: a review.Mikrochimica acta · 2019Article
- Bifunctional cleavable probes forChemical science · 2019Article
- Asking more from metabolic oligosaccharide engineering.Chemical science · 2018Review
- Mass Spectrometry Imaging: A Review of Emerging Advancements and Future Insights.Analytical chemistry · 2018Review
- L1210 Cells Overexpressing ABCB1 Drug Transporters Are Resistant to Inhibitors of the N- and O-glycosylation of Proteins.Molecules (Basel, Switzerland) · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glycans are crucial for many key biological processes and their alterations are often a hallmark of disease. Thus, multiplexed and sensitive analysis of glycans is of intense interest. Here we report a novel approach using DNA-mediated cell surface engineering for glycan profiling by MALDI-TOF mass spectrometry (MS). Following lectin binding, DNA amplification and hybridization, glycans on the cell surface are specifically labeled by short DNA probes, which can be facilely released, ionized and detected in MALDI-TOF MS. This strategy converts the analysis of glycans to the detection of DNA probes, overcoming the complicated composition and low ionization efficiency of glycans, enabling
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Registered trials
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