ArticleBiomicrofluidics2018
Biological characterization of the modified poly(dimethylsiloxane) surfaces based on cell attachment and toxicity assays.
Article in Biomicrofluidics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Core-Shell Biocompatible Piezoelectric Nanocomposite with Enhanced Cell Adhesion for Potential Biomedical Applications.ACS omega · 2026Article
- Planar Lipid Bilayers and Liposomes: Essential Models for Advancing Protein Structure and Function Research.Advances in experimental medicine and biology · 2026Review
- Fabrication of a five-layer wound dressing containing chitosan-LL37 peptide for the treatment of EB wounds and deep exudate patients.Iranian journal of basic medical sciences · 2026Article
- Article
- Biocompatibility Testing of UV-Curable Polydimethylsiloxane for Human Umbilical Vein Endothelial Cell Culture on-a-Chip.ACS omega · 2024Article
- Low-cost, versatile, and highly reproducible microfabrication pipeline to generate 3D-printed customised cell culture devices with complex designs.PLoS biology · 2024Article
- A programmable microfluidic platform to monitor calcium dynamics in microglia during inflammation.Microsystems & nanoengineering · 2024Article
- Recent Advances on Cell Culture Platforms for In Vitro Drug Screening and Cell Therapies: From Conventional to Microfluidic Strategies.Advanced healthcare materials · 2023Review
- Selective biofunctionalization of 3D cell-imprinted PDMS with collagen immobilization for targeted cell attachment.Scientific reports · 2022Article
- Review
- Protein Micropatterning in 2.5D: An Approach to Investigate Cellular Responses in Multi-Cue Environments.ACS applied materials & interfaces · 2021Article
- Fabrication of a microfluidic device for studying the combinatorial effect of physical and chemical cues on cell migration.STAR protocols · 2021Article
- Comprehensive Evaluation of Stable Neuronal Cell Adhesion and Culture on One-Step Modified Polydimethylsiloxane Using Functionalized Pluronic.ACS omega · 2020Article
- Surface Modification Techniques for Endothelial Cell Seeding in PDMS Microfluidic Devices.Biosensors · 2020Review
- Robust Formation of an Epithelial Layer of Human Intestinal Organoids in a Polydimethylsiloxane-Based Gut-on-a-Chip Microdevice.Frontiers in medical technology · 2020Article
- Fiber optic interferometric immunosensor based on polydimethilsiloxane (PDMS) and bioactive lipids.Biomedical optics express · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Poly(dimethylsiloxane) (PDMS) is a material applicable for tissue and biomedical engineering, especially based on microfluidic devices. PDMS is a material used in studies aimed at understanding cell behavior and analyzing the cell adhesion mechanism. In this work, biological characterization of the modified PDMS surfaces based on cell attachment and toxicity assays was performed. We studied Balb 3T3/c, HMEC-1, and HT-29 cell adhesion on poly(dimethylsiloxane) surfaces modified by different proteins, with and without pre-activation with plasma oxygen and UV irradiation. Additionally, we studied how changing of a base and a curing agent ratios influence cell proliferation. We observed that cell type has a high impact on cell adhesion, proliferation, as well as viability after drug exposure. It was tested that the carcinoma cells do not require a highly specific microenvironment for their proliferation. Cytotoxicity assays with celecoxib and oxaliplatin on the modified PDMS surfaces showed that normal cells, cultured on the modified PDMS, are more sensitive to drugs than cancer cells. Cell adhesion was also tested in the microfluidic systems made of the modified PDMS layers. Thanks to that, we studied how the surface area to volume ratio influences cell behavior. The results presented in this manuscript could be helpful for creation of proper culture conditions during
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.