ArticleScience and technology of advanced materials2018
Silver nanoparticles reduce the apoptosis induced by tumor necrosis factor-α.
Article in Science and technology of advanced materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
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- Silver nanoparticles induces apoptosis of cancer stem cells in head and neck cancer.Toxicology reports · 2024Article
- Advances in the Toxicity Assessment of Silver Nanoparticles Derived from aBiomolecules · 2024Article
- Recent advances in nanoparticle applications in respiratory disorders: a review.Frontiers in pharmacology · 2023Review
- Nanoparticle Effects on Stress Response Pathways and Nanoparticle-Protein Interactions.International journal of molecular sciences · 2022Review
- Inhalation exposure to silver nanoparticles induces hepatic inflammation and oxidative stress, associated with altered renin-angiotensin system signaling, in Wistar rats.Environmental toxicology · 2022Article
- Assembling p53 Activating Peptide With CeOFrontiers in bioengineering and biotechnology · 2022Article
- Recent Advances in Nano-Formulations for Skin Wound Repair Applications.Drug design, development and therapy · 2022Review
- Functional Hyaluronic Acid-Polylactic Acid/Silver Nanoparticles Core-Sheath Nanofiber Membranes for Prevention of Post-Operative Tendon Adhesion.International journal of molecular sciences · 2021Article
- Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing.Molecules (Basel, Switzerland) · 2021Article
- All That Glitters Is Not Silver-A New Look at Microbiological and Medical Applications of Silver Nanoparticles.International journal of molecular sciences · 2021Review
- Silver Nanoparticle-Coated Ethyl Cellulose Inhibits Tumor Necrosis Factor-α of Breast Cancer Cells.Drug design, development and therapy · 2021Article
- An In Vitro Lung System to Assess the Proinflammatory Hazard of Carbon Nanotube Aerosols.International journal of molecular sciences · 2020Article
- Size-Dependent Effect of Silver Nanoparticles on the Tumor Necrosis Factor α-Induced DNA Damage Response.International journal of molecular sciences · 2019Article
- UV cross-linked polyvinylpyrrolidone electrospun fibres as antibacterial surfaces.Science and technology of advanced materials · 2019Article
- Antimicrobial and Cytotoxicity Effects of Synthesized Silver Nanoparticles from Punica granatum Peel Extract.Nanoscale research letters · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Silver nanoparticles (AgNPs) are widely known to have anti-inflammatory properties, but the exact mechanism underlying this anti-inflammatory effect is not clearly understood. Tumor necrosis factor-α (TNFα) is a major pro-inflammatory cytokine that is expressed in the early stage of cell inflammation and induces apoptosis by several known pathways. Our study aimed to investigate the effect of AgNPs on the response of lung epithelial cells to TNFα and the molecular mechanism of this response. Lung epithelial cell line NCI-H292 cells were exposed to AgNPs (5 µg/mL) and/or TNFα (20 ng/mL) for 24 h, then cellular uptake was analyzed using flow cytometry. Our results showed that AgNPs were taken up by cells in a dose-dependent manner and that the cellular uptake ratio of AgNPs was significantly increased in the presence of TNFα. Apoptosis assays indicated that exposure to AgNPs significantly decreased the apoptotic effect of TNFα. Confocal microscopy was used to localize the tumor necrosis factor receptor 1 (TNFR1) and revealed that TNFR1 localized on the surface of cells exposed to TNFα. In contrast, TNFR1 localized inside cells exposed to both AgNPs and TNFα, with very few receptors scattered on the cell membrane. The results indicated that AgNPs reduced the cell surface TNFR1 expression level. The results suggested that the reduction of surface TNFR1 reduced cellular response to TNFα, resulting in an anti-apoptotic effect.
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