Evidence map›Paper›PMID 30034530›Full record

ReviewTherapeutic advances in gastroenterology2018

Chinese herbal medicine for functional dyspepsia: systematic review of systematic reviews.

Michael H K Chu, Irene X Y Wu, Robin S T Ho, Charlene H L Wong, Anthony L Zhang, Yan Zhang, Justin C Y Wu, Vincent C H Chung

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Therapeutic advances in gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Herbal Medicine Prescriptions for Functional Dyspepsia: A Nationwide Population-Based Study in Korea.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  10. Integrating Network Pharmacology andEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
  11. Article
  12. Review
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Michael H K ChuGlobal Physician-Leadership Stream, MBChB program, The Chinese University of Hong Kong, Hong Kong.
Irene X Y WuHong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, 5/F, School of Public Health Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong.
Robin S T HoJockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong.
Charlene H L WongHong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.
Anthony L ZhangChina-Australia International Research Centre for Chinese Medicine School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia Australian Research Centre in Complementary and Integrative Medicine (ARCCIM), University of Technology Sydney, Sydney, Australia.
Yan ZhangAustralian Research Centre in Complementary and Integrative Medicine (ARCCIM), University of Technology Sydney, Sydney, Australia Department of Family and Community Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Justin C Y WuHong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong.
Vincent C H ChungHong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong.
Chinese University of Hong Kong · CNHong Kong Jockey Club · CNPrince of Wales Hospital · CNTexas Tech University · USUniversity of Technology Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPharmacotherapy, including prokinetics and proton pump inhibitors for functional dyspepsia (FD) have limited effectiveness, and their safety has been recently questioned. Chinese herbal medicine (CHM) could be considered as an alternative. A systematic review (SR) of SRs was performed to evaluate the potential effectiveness and safety of CHM.

methodWe conducted a comprehensive literature search for SRs with meta-analyses in eight international and Chinese databases. Pooled effect estimation from each meta-analysis was extracted. The AMSTAR instrument was used to assess the methodological quality of the included SRs.

resultsA total of 14 SRs of mediocre quality assessing various CHMs, alone or in combination with conventional pharmacotherapy, were included. Meta-analyses showed that CHM was more effective than prokinetic agents for the alleviation of global dyspeptic symptoms. Three specific CHM formulae appeared to show superior results in the alleviation of global dyspeptic symptoms, including Si Ni San, modified Xiao Yao San and Xiang Sha Liu Jun Zi decoction. No significant difference in the occurrence of adverse events in using CHM or pharmacotherapy was reported.

conclusionCHM can be considered as an alternative for the treatment of FD symptoms when prokinetic agents and proton pump inhibitors are contraindicated. Future trial design should focus on measuring changes in individual dyspeptic symptoms and differentiate the effectiveness of different CHM for postprandial distress syndrome and epigastric pain syndrome. A network meta-analysis approach should be used to explore the most promising CHM formula for FD treatment in the future.

Indexed as

Chinese herbal medicineChinese herbsfunctional dyspepsiaprokineticsproton pump inhibitorssystematic reviews

Identifiers

PMID30034530
PMCPMC6048609
OpenAlexW2883958963

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.