Mining Big Neuron Morphological Data.

The advent of automatic tracing and reconstruction technology has led to a surge in the number of neurons 3D reconstruction data and consequently the neuromorphology research. However, the lack of machine-driven annotation schema to automatically detect the types of the neurons based on their morphology still hinders the development of this branch of science. Neuromorphology is important because of the interplay between the shape and functionality of neurons and the far-reaching impact on the diagnostics and therapeutics in neurological disorders. This survey paper provides a comprehensive research in the field of automatic neurons classification and presents the existing challenges, methods, tools, and future directions for automatic neuromorphology analytics. We summarize the major automatic techniques applicable in the field and propose a systematic data processing pipeline for automatic neuron classification, covering data capturing, preprocessing, analyzing, classification, and retrieval. Various techniques and algorithms in machine learning are illustrated and compared to the same dataset to facilitate ongoing research in the field.