Evidence map›Paper›PMID 30034323›Full record

ArticleFrontiers in cellular neuroscience2018

Corticotrophin-Releasing Factor Modulates Cerebellar Purkinje Cells Simple Spike Activity

Hong-Wei Wang, Jing-Tong Zhao, Bing-Xue Li, Shan-Shan Su, Yan-Hua Bing, Chun-Ping Chu, Wei-Ming Wang, Yu-Zi Li, De-Lai Qiu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Hong-Wei WangDepartment of Cardiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
Jing-Tong ZhaoKey Laboratory of Cellular Function and Pharmacology of Jilin Province, Yanbian University, Yanji, China.
Bing-Xue LiKey Laboratory of Cellular Function and Pharmacology of Jilin Province, Yanbian University, Yanji, China.
Shan-Shan SuKey Laboratory of Cellular Function and Pharmacology of Jilin Province, Yanbian University, Yanji, China.
Yan-Hua BingKey Laboratory of Cellular Function and Pharmacology of Jilin Province, Yanbian University, Yanji, China.
Chun-Ping ChuKey Laboratory of Cellular Function and Pharmacology of Jilin Province, Yanbian University, Yanji, China.
Wei-Ming WangDepartment of Osteology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
Yu-Zi LiDepartment of Cardiology, Affiliated Hospital of Yanbian University, Yanji, China.
De-Lai QiuKey Laboratory of Cellular Function and Pharmacology of Jilin Province, Yanbian University, Yanji, China.
Yanbian University · CNAffiliated Zhongshan Hospital of Dalian University · CNYanbian University Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Corticotropin-releasing factor (CRF) is a major neuromodulator that modulates cerebellar neuronal activity via CRF receptors during stress responses. In the cerebellar cortex, CRF dose-dependently increases the simple spike (SS) firing rate of Purkinje cells (PCs), while the synaptic mechanisms of this are still unclear. We here investigated the effect of CRF on the spontaneous SS activity of cerebellar PCs in urethane-anesthetized mice by

Indexed as

cerebellar Purkinje cellcomplex spike (CS)corticotropin-releasing factor (CRF)in vivo whole-cell patch-clamp recordingminiature postsynaptic currentsprotein kinase A (PKA)simple-spike (SS)

Identifiers

PMID30034323
PMCPMC6043798
OpenAlexW2808351403

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.