Evidence map›Paper›PMID 30034223›Full record

ArticleDrug design, development and therapy2018

Antifungal activity of

Roberta Gaziano, Elena Campione, Federico Iacovelli, Daniele Marino, Francesca Pica, Paolo Di Francesco, Stefano Aquaro, Francesco Menichini, Mattia Falconi, Luca Bianchi

Open access · goldAbstract read
In one paragraph

Article in Drug design, development and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Antimicrobial evaluation ofFrontiers in microbiology · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Design of a Nasal Spray Based onMolecules (Basel, Switzerland) · 2021
    Article
  10. Retinoids in Fungal Infections: From Bench to Bedside.Pharmaceuticals (Basel, Switzerland) · 2021
    Review
  11. Antifungal Effect of All-Antimicrobial agents and chemotherapy · 2021
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Roberta GazianoMicrobiology Section, Department of Experimental Medicine and Surgery, University of Rome 'Tor Vergata', Rome, Italy.
Elena CampioneDepartment of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy, luca.bianchi@uniroma2.it.
Federico IacovelliDepartment of Biology, University of Rome 'Tor Vergata', Rome, Italy, falconi@uniroma2.it.
Daniele MarinoMicrobiology Section, Department of Experimental Medicine and Surgery, University of Rome 'Tor Vergata', Rome, Italy.
Francesca PicaMicrobiology Section, Department of Experimental Medicine and Surgery, University of Rome 'Tor Vergata', Rome, Italy.
Paolo Di FrancescoMicrobiology Section, Department of Experimental Medicine and Surgery, University of Rome 'Tor Vergata', Rome, Italy.
Stefano AquaroDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
Francesco MenichiniDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
Mattia FalconiDepartment of Biology, University of Rome 'Tor Vergata', Rome, Italy, falconi@uniroma2.it.
Luca BianchiDepartment of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy, luca.bianchi@uniroma2.it.
University of Rome Tor Vergata · ITUniversity of Calabria · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDermatophytosis is a superficial fungal infection limited to the stratum corneum of the epidermis, or to the hair and nails, and constitutes an important public health problem because of its high prevalence and associated morbidity. Dermatophyte fungi, especially 2 species,

methodsWe investigated in vitro the effect of different concentrations of

resultsOur results indicate a clear-cut antifungal activity of the total plant extract at the highest concentrations (500 and 250 µg). Among all tested

conclusionOur data indicate a strong fungistatic effect of

Indexed as

Antifungal AgentsDose-Response Relationship, DrugHSP90 Heat-Shock ProteinsMicrobial Sensitivity TestsModels, MolecularPlant ExtractsPlants, MedicinalSapindaceaeStructure-Activity RelationshipTrichophytonAntifungal AgentsHSP90 Heat-Shock ProteinsPlant Extractsantifungal activityCardiospermum halicacabumdermatophytosesHsp90luteolinmolecular dockingmolecular modelingrutinTrichophyton rubrum

Identifiers

PMID30034223
PMCPMC6047602
OpenAlexW2840862306

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.