Evidence map›Paper›PMID 30033597›Full record

ArticleCancer science2018

LncNEN885 inhibits epithelial-mesenchymal transition by partially regulation of Wnt/β-catenin signalling in gastroenteropancreatic neuroendocrine neoplasms.

Ya-Ling Wei, Jie Hua, Xiao-Yu Liu, Xiu-Mei Hua, Cheng Sun, Jian-An Bai, Qi-Yun Tang

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ya-Ling WeiDepartment of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Jie HuaDepartment of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Xiao-Yu LiuKey Laboratory for Neuroregeneration of Jiangsu Province and Education Ministry, Nantong University, Nantong, China.
Xiu-Mei HuaDepartment of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Cheng SunKey Laboratory for Neuroregeneration of Jiangsu Province and Education Ministry, Nantong University, Nantong, China.
Jian-An BaiDepartment of Gastroenterology, The Affiliated Sir Run Run Hospital of Nanjing Medical University, Nanjing, China.ORCID http://orcid.org/0000-0001-7822-7297
Qi-Yun TangDepartment of General Practice, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Nanjing Medical University · CNNantong University · CN

Funding

"333" Project of Jiangsu Province BRA2017535Medical Key Talents Project of Jiangsu Province ZDRCA2016008
6 · The paper itself

Abstract

It has been shown that long noncoding RNAs (lncRNAs) are involved in the carcinogenesis of multiple cancers. However, the roles of lncRNAs in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) remain elusive. In the present study, we found that lncNEN885 was markedly decreased in human gastric NEN samples compared to adjacent normal tissues by transcriptome sequencing. Functionally, silencing or overexpression of lncNEN885 could not obviously affect cell proliferation or apoptosis in BON-1 or LCC-18 cells but could affect cell migration and invasion as well as wound-healing rates. Furthermore, dysregulation of lncNEN885 affected these biological functions by activating epithelial-mesenchymal transition through increased expression of Snail, vimentin, and N-cadherin as well as decreased E-cadherin levels in BON-1 and LCC-18 cells. Silencing of lncNEN885 could dramatically increase the phosphorylation of glycogen synthase kinase-3β and decrease the expression of adenomatous polyposis coli and Axin, with the subsequent accumulation of β-catenin. Taken together, dysregulation of lncNEN885 can regulate cell migration and invasion by activating epithelial-mesenchymal transition process partially through canonical Wnt/β-catenin signaling in GEP-NEN cells, which may be a novel biomarker for the metastasis of GEP-NENs.

Indexed as

Gene Expression Regulation, NeoplasticApoptosisbeta CateninCell MovementCell ProliferationEpithelial-Mesenchymal TransitionGastrointestinal NeoplasmsGene Expression ProfilingHumansNeoplasm InvasivenessNeuroendocrine TumorsPancreatic NeoplasmsPhosphorylationRNA, Long NoncodingRNA, Small InterferingStomachbeta CateninCTNNB1 protein, humanRNA, Long NoncodingRNA, Small InterferingBON-1 cellepithelial-mesenchymal transitionlncNEN885neuroendocrine neoplasmWnt/β-catenin signaling

Identifiers

PMID30033597
PMCPMC6172073
OpenAlexW2884866467

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.