Evidence map›Paper›PMID 30033343›Full record

ReviewTrends in microbiology2019

Exploitation of Cytoskeletal Networks during Early Viral Infection.

Derek Walsh, Mojgan H Naghavi

Abstract readReview
In one paragraph

Review in Trends in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Effects ofViruses · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Myosin IXB protects immune cells from virus infection.The Journal of general virology · 2025
    Article
  12. Article
  13. Article
  14. Proteomics analysis of soluble secreted proteins ofFrontiers in cellular and infection microbiology · 2025
    Article
  15. Article
  16. Review
  17. Cytoskeleton-associated gelsolin responds to the midgut distention process in saline meal-fed Aedes aegypti and affects arbovirus dissemination from the midgut.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  18. Review
  19. Article
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Derek WalshDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Mojgan H NaghaviDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: Mojgan.naghavi@northwestern.edu.

Funding

The Role of the Microtubule Regulators Kif4 and EB1 in HIV-1 InfectionP01GM105536 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GUNDERSEN, GREGG G, NAGHAVI, MOJGAN HOSSEINI · 2014 to 2018
$7.5M
Characterization of the antiviral and nuclear regulatory functions of FEZ1 & NEK1R01GM101975 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI NAGHAVI, MOJGAN HOSSEINI · 2012 to 2016
$1.6M
NIGMS NIH HHS P01 GM105536NIGMS NIH HHS R01 GM101975
6 · The paper itself

Abstract

Being dependent upon host transport systems to navigate the cytoplasm, viruses have evolved various strategies to manipulate cytoskeletal functions. Generally, viruses use the actin cytoskeleton to control entry and short-range transport at the cell periphery and exploit microtubules (MTs) for longer-range cytosolic transport, in some cases to reach the nucleus. While earlier studies established the fundamental importance of these networks to successful infection, the mechanistic details and true extent to which viruses usurp highly specialized host cytoskeletal regulators and motor adaptors is only beginning to emerge. This review outlines our current understanding of how cytoskeletal regulation contributes specifically to the early stages of viral infection, with a primary focus on retroviruses and herpesviruses as examples of recent advances in this area.

Indexed as

Host-Pathogen InteractionsVirus InternalizationVirus ReleaseVirus ReplicationBiological TransportCytoskeletonVirus Diseasesactinmicrotubulesmotorstraffickinguncoatingviruses

Identifiers

PMID30033343
PMCPMC6309480

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.