ArticleCurrent biology : CB2018
CLAVATA Was a Genetic Novelty for the Morphological Innovation of 3D Growth in Land Plants.
Article in Current biology : CB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 67 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
67 citing papers in PubMed, 164 citations in OpenAlex.
- System drift in the evolution of plant meristem development.PLoS genetics · 2026Article
- Regulatory layers of robustness of CLAVATA-WUSCHEL feedback system in stem cell homeostasis.Frontiers in plant science · 2026Review
- Upstairs, downstairs: conserved and divergent CLAVATA signalling in shoot meristem development and root symbioses.Annals of botany · 2025Review
- CLE pathways in plant development: recent advances and future perspectives.Journal of experimental botany · 2025Review
- An updated history of TDIF-PXY signalling: a study in cell fate and tissue patterning.The New phytologist · 2025Review
- Bryophytes hold a larger gene family space than vascular plants.Nature genetics · 2025Article
- A FLOE-related protein regulates the two-dimensional to three-dimensional growth transition in the moss Physcomitrium patens.Development (Cambridge, England) · 2025Article
- Diversification of CLE expression patterns and nonmeristematic roles for CLAVATA receptor-like kinases in a moss.The New phytologist · 2025Article
- In defense of funding foundational plant science.The Plant cell · 2025Article
- The rise of CLAVATA: evidence for CLAVATA3 and WOX signaling in the fern gametophyte.The Plant journal : for cell and molecular biology · 2025Article
- CLE peptides act via the receptor-like kinase CRINKLY 4 inPlant signaling & behavior · 2024Article
- Cytokinin and ALOG proteins regulate pluripotent stem cell identity in the mossScience advances · 2024Article
- The landscape of transcription factor promoter activity during vegetative development in Marchantia.The Plant cell · 2024Article
- Regulation of developmental gatekeeping and cell fate transition by the calpain protease DEK1 in Physcomitrium patens.Communications biology · 2024Article
- CLAVATA signaling in plant-environment interactions.Plant physiology · 2024Review
- Bioassays for Identifying and Characterizing Plant Regulatory Peptides.Biomolecules · 2023Review
- Functional Modules in the Meristems: "Tinkering" in Action.Plants (Basel, Switzerland) · 2023Review
- Asymmetric Evolution of Protein Domains in the Leucine-Rich Repeat Receptor-Like Kinase Family of Plant Signaling Proteins.Molecular biology and evolution · 2023Article
- The TOPLESS corepressor regulates developmental switches in the bryophyte Physcomitrium patens that were critical for plant terrestrialisation.The Plant journal : for cell and molecular biology · 2023Article
- Restructuring plant types for developing tailor-made crops.Plant biotechnology journal · 2023Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
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- Erratum issued
Authors and funding
15 authors at 6 institutions in 3 countries.
Funding
Abstract
How genes shape diverse plant and animal body forms is a key question in biology. Unlike animal cells, plant cells are confined by rigid cell walls, and cell division plane orientation and growth rather than cell movement determine overall body form. The emergence of plants on land coincided with a new capacity to rotate stem cell divisions through multiple planes, and this enabled three-dimensional (3D) forms to arise from ancestral forms constrained to 2D growth. The genes involved in this evolutionary innovation are largely unknown. The evolution of 3D growth is recapitulated during the development of modern mosses when leafy shoots arise from a filamentous (2D) precursor tissue. Here, we show that a conserved, CLAVATA peptide and receptor-like kinase pathway originated with land plants and orients stem cell division planes during the transition from 2D to 3D growth in a moss, Physcomitrella. We find that this newly identified role for CLAVATA in regulating cell division plane orientation is shared between Physcomitrella and Arabidopsis. We report that roles for CLAVATA in regulating cell proliferation and cell fate are also shared and that CLAVATA-like peptides act via conserved receptor components in Physcomitrella. Our results suggest that CLAVATA was a genetic novelty enabling the morphological innovation of 3D growth in land plants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.