Evidence map›Paper›PMID 30033086›Full record

ArticleStem cell reports2018

The AMPK/p27

James P White, Andrew N Billin, Milton E Campbell, Alan J Russell, Kim M Huffman, William E Kraus

Open access · goldAbstract read
In one paragraph

Article in Stem cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. A Myocyte-Enriched Long Non-Coding RNA NRMLncR Enhances Myogenesis in Mouse.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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  10. Resistance-based exercise restores muscle health in dialysis patients.Journal of muscle research and cell motility · 2026
    Article
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  12. bioRxiv : the preprint server for biology · 2026
    Article
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

James P WhiteDivision of Hematology, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC 27701, USA. Electronic address: james.white@duke.edu.
Andrew N BillinMuscle Metabolism Discovery Performance Unit, Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia, PA 19406, USA.
Milton E CampbellDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA.
Alan J RussellMuscle Metabolism Discovery Performance Unit, Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia, PA 19406, USA.
Kim M HuffmanDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC 27701, USA; Division of Rheumatology, Duke University School of Medicine, Durham, NC 27701, USA.
William E KrausDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC 27701, USA; Division of Cardiology, Duke University School of Medicine, Durham, NC 27701, USA.
Duke University · USGlaxoSmithKline (United States) · USPathways Behavioral Services · US

Funding

Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Sarah B. Peskoe · 2006 to 2026
$24.6M
The AMPK/ULK1/p27Kip1 axis regulates autophagy and cell survival in aged satellite cellsK01AG056664 · NIA · DUKE UNIVERSITY · PI WHITE, JAMES P. · 2017 to 2022
$913k
NIA NIH HHS K01 AG056664NIA NIH HHS P30 AG028716
6 · The paper itself

Abstract

Skeletal muscle stem cell (MuSC) function declines with age and contributes to impaired muscle regeneration in older individuals. Acting through AMPK/p27

Indexed as

ApoptosisAutophagyAge FactorsAMP-Activated Protein KinasesAnimalsCellular SenescenceCyclin-Dependent Kinase Inhibitor p27MiceModels, BiologicalMuscle DevelopmentPhosphorylationSatellite Cells, Skeletal MuscleStem CellsAMP-Activated Protein KinasesCyclin-Dependent Kinase Inhibitor p27agingAMPKapoptosisautophagycaloric restrictioncell transplantationmuscle stem cellp27Kip1regenerationsenescence

Identifiers

PMID30033086
PMCPMC6093087
OpenAlexW2884425253

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.