Evidence map›Paper›PMID 30033030›Full record

ArticleThe American journal of pathology2018

Innate Immune Cells Are Regulated by Axl in Hypertensive Kidney.

Sri N Batchu, George J Dugbartey, Kristine M Wadosky, Deanne M Mickelsen, Kyung A Ko, Ronald W Wood, Yuqi Zhao, Xia Yang, Deborah J Fowell, Vyacheslav A Korshunov

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Sri N BatchuDepartment of Medicine and Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York.
George J DugbarteyDepartment of Medicine and Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Kristine M WadoskyDepartment of Medicine and Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Deanne M MickelsenDepartment of Medicine and Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Kyung A KoDepartment of Medicine and Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Ronald W WoodDepartment of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Yuqi ZhaoDepartment of Integrative Biology and Physiology, University of California, Los Angeles, California.
Xia YangDepartment of Integrative Biology and Physiology, University of California, Los Angeles, California.
Deborah J FowellDepartment of Microbiology and Immunology and David H. Smith Center for Vaccine Biology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Vyacheslav A KorshunovDepartment of Medicine and Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York; Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York. Electronic address: slava_korshunov@urmc.rochester.edu.
University of Rochester · USUniversity of California, Los Angeles · US

Funding

Tissue regulation of T cell function - Reagents CoreP01AI102851 · NIAID · UNIVERSITY OF ROCHESTER · PI Iwijn De Vlaminck · 2014 to 2026
$26.0M
DHA Reverses Gene Network Signatures of Fructose-induced Metabolic SyndromeR01DK104363 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YANG, XIA · 2015 to 2019
$2.4M
The Role of Immune Response in Vascular Dysfunction in HypertensionR01HL105623 · NHLBI · UNIVERSITY OF ROCHESTER · PI KORSHUNOV, VYACHESLAV A · 2011 to 2015
$1.5M
NHLBI NIH HHS R01 HL105623NIAID NIH HHS P01 AI102851NIDDK NIH HHS R01 DK104363
6 · The paper itself

Abstract

The balance between adaptive and innate immunity in kidney damage in salt-dependent hypertension is unclear. We investigated early renal dysfunction and the influence of Axl, a receptor tyrosine kinase, on innate immune response in hypertensive kidney in mice with lymphocyte deficiency (Rag1

Indexed as

AnimalsAxl Receptor Tyrosine KinaseCells, CulturedComplement C3Homeodomain ProteinsHypertensionImmunity, InnateKidney DiseasesLymphocytesMaleMiceMice, Inbred C57BLMice, KnockoutProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesSignal TransductionAxl Receptor Tyrosine KinaseAXL receptor tyrosine kinase, mouseComplement C3Homeodomain ProteinsProto-Oncogene ProteinsRAG-1 proteinReceptor Protein-Tyrosine Kinases

Identifiers

PMID30033030
PMCPMC6099337
OpenAlexW2884251740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.