ArticleDevelopmental cell2018
Fish Scales Dictate the Pattern of Adult Skin Innervation and Vascularization.
Article in Developmental cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Peripheral mechanisms of tactile sensation in fish.Current opinion in neurobiology · 2026Review
- Combined mutations of hoxa13a, hoxa13b, and hoxd13a lead to structural shifts in zebrafish soft fin rays providing insight into spiny ray evolution.PLoS genetics · 2026Article
- Dendritic atoh1a+ cells serve as Merkel cell precursors during skin development and regeneration.Development (Cambridge, England) · 2025Article
- Organoid-Like Neurovascular Spheroids Promote the Recovery of Hypoxic-Ischemic Skin Flaps Through the Activation of Autophagy.Advanced healthcare materials · 2025Article
- Phased ERK responsiveness and developmental robustness regulate teleost skin morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Calcium dynamics of skin-resident macrophages during homeostasis and tissue injury.Molecular biology of the cell · 2024Article
- Calcium dynamics of skin-resident macrophages during homeostasis and tissue injury.bioRxiv : the preprint server for biology · 2024Article
- Molecular regulation of axon termination in mechanosensory neurons.Development (Cambridge, England) · 2024Review
- Adaptive patterning of vascular network during avian skin development: Mesenchymal plasticity and dermal vasculogenesis.Cells & development · 2024Article
- Keratinocytes drive the epithelial hyperplasia key to sea lice resistance in coho salmon.BMC biology · 2024Article
- Dermal Dive: An Overview of Cutaneous Wounding Techniques in Zebrafish.The Journal of investigative dermatology · 2024Review
- Anatomy, development and regeneration of zebrafish elasmoid scales.Developmental biology · 2024Article
- Rho-associated kinase regulates Langerhans cell morphology and responsiveness to tissue damage.Cell reports · 2024Article
- Single-Cell Analysis of Rohon-Beard Neurons Implicates Fgf Signaling in Axon Maintenance and Cell Survival.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Live Imaging of Cutaneous Wound Healing after Rotary Tool Injury in Zebrafish.The Journal of investigative dermatology · 2024Article
- Article
- Quantitative Live Imaging of Zebrafish Scale Regeneration: From Adult Fish to Signaling Patterns and Tissue Flows.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Histological and ultrastructural characterization of the dorso-ventral skin of the juvenile and the adult starry puffer fish (Arothron stellatus, Anonymous 1798).BMC veterinary research · 2023Article
- Article
- The hidden depths of zebrafish skin.eLife · 2023Article
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Funding
Abstract
As animals mature from embryonic to adult stages, the skin grows and acquires specialized appendages, like hairs, feathers, and scales. How cutaneous blood vessels and sensory axons adapt to these dramatic changes is poorly understood. By characterizing skin maturation in zebrafish, we discovered that sensory axons are delivered to the adult epidermis in organized nerves patterned by features in bony scales. These nerves associate with blood vessels and osteoblasts above scales. Osteoblasts create paths in scales that independently guide nerves and blood vessels during both development and regeneration. By preventing scale regeneration and examining mutants lacking scales, we found that scales recruit, organize, and polarize axons and blood vessels to evenly distribute them in the skin. These studies uncover mechanisms for achieving comprehensive innervation and vascularization of the adult skin and suggest that scales coordinate a metamorphosis-like transformation of the skin with sensory axon and vascular remodeling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.