ArticleDevelopmental cell2018
Yorkie Functions at the Cell Cortex to Promote Myosin Activation in a Non-transcriptional Manner.
Article in Developmental cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- Review
- Noncanonical role of Golgi-associated macrophage TAZ in chronic inflammation and tumorigenesis.Science advances · 2025Article
- Yellow and oxidation-resistant derivatives of a monomeric superfolder GFP.Molecular biology of the cell · 2024Article
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- The Hippo kinase cascade regulates a contractile cell behavior and cell density in a close unicellular relative of animals.bioRxiv : the preprint server for biology · 2024Article
- Cortical tension promotes Kibra degradation via Par-1.Molecular biology of the cell · 2024Article
- The Interaction of Mechanics and the Hippo Pathway inCancers · 2023Article
- Article
- Genome editing in the unicellular holozoaneLife · 2022Article
- Metabolic control of progenitor cell propagation during Drosophila tracheal remodeling.Nature communications · 2022Article
- Hippo signaling in cardiac fibroblasts during development, tissue repair, and fibrosis.Current topics in developmental biology · 2022Review
- Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface.International journal of molecular sciences · 2021Review
- Non-muscle myosin II activation: adding a classical touch to ROCK.Small GTPases · 2021Article
- Article
- Article
- A loss-of-function NUAK2 mutation in humans causes anencephaly due to impaired Hippo-YAP signaling.The Journal of experimental medicine · 2020Article
- The Molecular Network of YAP/Yorkie at the Cell Cortex and their Role in Ocular Morphogenesis.International journal of molecular sciences · 2020Review
- Yap/Taz promote the scavenging of extracellular nutrients through macropinocytosis.Genes & development · 2020Article
- Mask, a component of the Hippo pathway, is required for Drosophila eye morphogenesis.Developmental biology · 2020Article
- Mob Family Proteins: Regulatory Partners in Hippo and Hippo-Like Intracellular Signaling Pathways.Frontiers in cell and developmental biology · 2020Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The Hippo signaling pathway is an evolutionarily conserved mechanism that controls organ size in animals. Yorkie is well known as a transcriptional co-activator that functions downstream of the Hippo pathway to positively regulate transcription of genes that promote tissue growth. Recent studies have shown that increased myosin activity activates both Yorkie and its vertebrate orthologue YAP, resulting in increased nuclear localization and tissue growth. Here we show that Yorkie also can accumulate at the cell cortex in the apical junctional region. Moreover, Yorkie functions at the cortex to promote activation of myosin through a myosin regulatory light chain kinase, Stretchin-Mlck. This Yorkie function is not dependent on its transcriptional activity and is required for larval and adult tissues to achieve appropriate size. Based on these results, we suggest that Yorkie functions in a feedforward "amplifier" loop that promotes myosin activation, and thereby greater Yorkie activity, in response to tension.
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