Evidence map›Paper›PMID 30032422›Full record

ArticleMolecular neurobiology2019

The Role of Methylated Circulating Nucleic Acids as a Potential Biomarker in Alzheimer's Disease.

Ming-Chyi Pai, Yu-Min Kuo, I-Fang Wang, Po-Min Chiang, Kuen-Jer Tsai

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
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  4. Detection of Brain-Derived Cell-Free DNA in Plasma.Diagnostics (Basel, Switzerland) · 2024
    Article
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  7. Article
  8. Article
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  12. Cell-free DNA-based liquid biopsies in neurology.Brain : a journal of neurology · 2023
    Review
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  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Ming-Chyi PaiDivision of Behavioural Neurology, Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yu-Min KuoAlzheimer's Disease Research Centre, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
I-Fang WangInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, 704, Taiwan.
Po-Min ChiangInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, 704, Taiwan.
Kuen-Jer TsaiAlzheimer's Disease Research Centre, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. kjtsai@mail.ncku.edu.tw.ORCID http://orcid.org/0000-0002-2170-9735
National Cheng Kung University Hospital · TWInstitute of Molecular Biology, Academia Sinica · TWNational Cheng Kung University · TW

Funding

Ministry of Health (TW) DOH101-TD-B-111-0002Ministry of Science and Technology, Taiwan MOST-104-2745-B-006-001Ministry of Science and Technology, Taiwan MOST-105-2628-B-006-016-MY3Ministry of Science and Technology, Taiwan MOST-106-2628-B-006-001-MY4NCKU Hospital Medical Center NCKUH-10006002
6 · The paper itself

Abstract

Previous studies report detection of high concentrations of circulating nucleic acids (CNAs), which are likely related to cell apoptosis, in the plasma of patients with cancers, stroke, trauma, and relapsing-remitting multiple sclerosis. However, the relationship between Alzheimer's disease (AD) and CNAs is unclear. A total of 36 adult participants (9 non-demented controls and 27 patients with AD) and patients with mild AD, who met the criteria for probable AD, were enrolled in the present study, which was conducted at the Department of Neurology of National Cheng Kung University Hospital. The CNA levels were increased in the plasma of patients with AD, culture medium of amyloid-β-treated SH-SY5Y cells, and plasma from a mouse model of AD. The CNA concentrations in the plasma were positively correlated with the cognitive scores. Further, CNAs in patients with AD contained neuronal tissue-specific methylated LHX2, at CpG sites 1 and 5. These results showed that the increased levels of plasma CNAs could be related to neuronal cell death that was induced by β-amyloid toxicity. Thus, the results suggested that the levels of plasma CNAs and LHX2 methylation might serve as potential biomarkers for the diagnosis of AD, particularly during the early stages of the disease.

Indexed as

Alzheimer DiseaseAnimalsBase SequenceBiomarkersCell-Free Nucleic AcidsCell Line, TumorCognitionDNA MethylationHumansLIM-Homeodomain ProteinsMice, TransgenicNeuronsOrgan SpecificityTranscription FactorsBiomarkersCell-Free Nucleic AcidsLHX2 protein, humanLIM-Homeodomain ProteinsTranscription FactorsAlzheimer’s diseaseApoptosisCirculating nucleic acidsMethylation

Identifiers

PMID30032422
OpenAlexW2882971869

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.