ArticleJournal of neurology2018
Gluten neuropathy: prevalence of neuropathic pain and the role of gluten-free diet.
Article in Journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05165368 (Effect of Gluten-Free Dietary Education and Intraneural Facilitation® Therapy on Quality of Life in People With Diabetic Neuropathy), which is not on this map. Cited by 24 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Gluten-Free Dietary Education and Intraneural Facilitation® Therapy on Quality of Life in People With Diabetic Neuropathy
Who cites it
24 citing papers in PubMed, 5 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Repetitive Magnetic Stimulation for the Management of Peripheral Neuropathic Pain: A Systematic Review.Advances in therapy · 2020Pooled it
- Alcohol-related peripheral neuropathy: a systematic review and meta-analysis.Journal of neurology · 2019Pooled it
- Neurological Manifestations of Neuropathy and Ataxia in Celiac Disease: A Systematic Review.Nutrients · 2019Pooled it
- Quality of Life in Painful Peripheral Neuropathies: A Systematic Review.Pain research & management · 2019Pooled it
- Pooled it
- Shared Immune and Nutrient Metabolism Pathways Between Autism Spectrum Disorder and Celiac Disease: An In Silico Approach.Nutrients · 2025Article
- A Retrospective Assessment of Neuropathic Pain in Response to Intraneural FacilitationBiomedicines · 2025Article
- Effects of Physical Cues on Stem Cell-Derived Extracellular Vesicles toward Neuropathy Applications.Biomedicines · 2024Review
- What's New in Neuropathy?Cureus · 2023Review
- Review article: Systemic consequences of coeliac disease.Alimentary pharmacology & therapeutics · 2022Review
- Sudomotor dysfunction in patients with gluten neuropathy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Review
- Acrodystrophic axonal polyneuropathy with celiac disease: a case report.Journal of medical case reports · 2021Article
- Pharmacological Management of Painful Peripheral Neuropathies: A Systematic Review.Pain and therapy · 2021Review
- Gluten neuropathy: electrophysiological progression and HLA associations.Journal of neurology · 2021Article
- Food in Chronic Pain: Friend or Foe?Nutrients · 2020Article
- Brain Opioid Activity and Oxidative Injury: Different Molecular Scenarios Connecting Celiac Disease and Autistic Spectrum Disorder.Brain sciences · 2020Review
- Pain in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Systematic Review and Meta-Analysis.Pain and therapy · 2019Review
- Scientific Advances in and Clinical Approaches to Small-Fiber Polyneuropathy: A Review.JAMA neurology · 2019Article
- Going Against the Grains: Gluten-Free Diets in Patients Without Celiac Disease-Worthwhile or Not?Digestive diseases and sciences · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimPeripheral neuropathy is a common extraintestinal manifestation of gluten sensitivity (gluten neuropathy). We aimed to establish the prevalence of neuropathic pain in patients with otherwise idiopathic PN and gluten sensitivity (positive antigliadin, endomysial, and/or transglutaminase antibodies, with or without enteropathy) and to describe any contributory factors.
methodsAll consecutive patients with gluten neuropathy (GN) attending a specialist gluten/neurology clinic were invited to participate. Pain was assessed via the DN4 questionnaire and the visual analog scale. Overall Neuropathy Limitations Scale was used to assess the severity of neuropathy. The Mental Health Index (MHI-5) was used to measure participants' general mental health status.
resultsIn total, 60 patients (76.7% males, mean age 69.9 ± 10.1 years) with GN were recruited. Neuropathic pain was present in 33 patients (55.0%). Comparison between groups of painful and not painful GN did not show significant differences regarding age, gender, neuropathy severity and neuropathy type. Patients with painless GN were more likely to be on a strict gluten-free diet (55.6 versus 21.2%, p = 0.006). Patients with painful GN presented with significantly worse MHI-5 score (75.9 ± 13.8 versus 87.4 ± 8.1, p < 0.001). Multivariate analysis showed that, after adjusting for age, gender and MHI-5, strict gluten-free diet was associated with lowering the odds of peripheral neuropathic pain by 88.7% (95% CI 47.2-97.6%, p = 0.006).
conclusionNeuropathic pain is very prevalent in GN and is associated with poorer mental health status. Strict gluten-free diet might be protective as it is associated with a significant reduction of the odds of peripheral neuropathic pain associated to GN.
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