Evidence map›Paper›PMID 30032335›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2019

High-resolution axon reflex sweat testing for diagnosis of neuropathy.

Adam Loavenbruck, Nathan Sit, Vincenzo Provitera, William Kennedy

Abstract read
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In one paragraph

Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Adam LoavenbruckDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA. loave001@umn.edu.ORCID http://orcid.org/0000-0002-1206-2095
Nathan SitDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Vincenzo ProviteraTelese Terme, 'S. Maugeri' Foundation IRCCS, Benevento, Italy.
William KennedyDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
University of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to report a method that quantifies axon reflex sweating from individual sweat glands with nanoliter precision. Measurement of the axon reflex is generally expressed as a single variable (e.g., the flare area or total sweat volume). High-definition videography enables precise measurement of sweating from single, axon reflex-stimulated sweat glands (SGs).

methodsThe sudomotor axon reflex was activated in healthy subjects and subjects with peripheral neuropathy by iontophoresis of 10% acetylcholine. Sweating was simultaneously imaged for 5 min in a 2.5-cm

resultsFifty-two healthy control and twenty subjects with neuropathy underwent testing at the foot, calf, thigh, and hand. Normal ranges were calculated for SG density, mean sweat rate per SG, and total sweat volume. Neuropathy subjects demonstrated reduced sweating, and values differed between body sites.

interpretationThe described method precisely measures the total and individual sweat output of hundreds of SGs in response to a standard, axon reflex-mediated stimulus, and quantifies alterations in axon reflex sweating seen in peripheral neuropathy.

Indexed as

AdultAgedAged, 80 and overAxonsFemaleHumansIontophoresisMaleMiddle AgedPeripheral Nervous System DiseasesReflexSweatSweatingYoung AdultAutonomic nervous systemAutonomic testingAxon reflexQuantitative sudomotor axon reflex testingSweat testing

Identifiers

PMID30032335
OpenAlexW2883498256

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.