Evidence map›Paper›PMID 30032228›Full record

SynthesisAdvances in nutrition (Bethesda, Md.)2018

Associations between Single Nucleotide Polymorphisms and Total Energy, Carbohydrate, and Fat Intakes: A Systematic Review.

Theresa Drabsch, Jennifer Gatzemeier, Lisa Pfadenhauer, Hans Hauner, Christina Holzapfel

Abstract readSystematic Review
In one paragraph

Synthesis in Advances in nutrition (Bethesda, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Tackling Atherosclerosis via Selected Nutrition.International journal of molecular sciences · 2022
    Review
  5. TheCurrent developments in nutrition · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Associations ofGenes · 2021
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Theresa DrabschInstitute for Nutritional Medicine, University Hospital Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Jennifer GatzemeierInstitute for Nutritional Medicine, University Hospital Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Lisa PfadenhauerInstitute for Medical Informatics, Biometry, and Epidemiology, Ludwig Maximilians University Munich, Munich, Germany.
Hans HaunerInstitute for Nutritional Medicine, University Hospital Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Christina HolzapfelInstitute for Nutritional Medicine, University Hospital Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A better understanding of the genetic underpinning of total energy, carbohydrate, and fat intake is a prerequisite to develop personalized dietary recommendations. For this purpose, we systematically reviewed associations between single nucleotide polymorphisms (SNPs) and total energy, carbohydrate, and fat intakes. Four databases were searched for studies that assessed an association between SNPs and total energy, carbohydrate, and fat intakes. Screening of articles and data extraction was performed independently by 2 reviewers. Articles in English or German language, published between 1994 and September 2017, on human studies in adults and without specific populations were considered for the review. In total, 39 articles, including 86 independent loci, met the inclusion criteria. The fat mass and obesity-associated (FTO) gene as well as the melanocortin 4 receptor (MC4R) locus were most frequently studied. Limited significant evidence of an association between the FTO SNP rs9939609 and lower total energy intake and between the MC4R SNP rs17782313 and higher total energy intake was reported. Most of the other identified loci showed inconsistent results. In conclusion, there is no consistent evidence that the investigated SNPs are associated with and predictive for total energy, carbohydrate, and fat intakes.

Indexed as

Polymorphism, Single NucleotideAdultAgedAlpha-Ketoglutarate-Dependent Dioxygenase FTOBody CompositionBody Mass IndexDietary CarbohydratesDietary FatsEnergy IntakeFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedObesityReceptor, Melanocortin, Type 4Alpha-Ketoglutarate-Dependent Dioxygenase FTODietary CarbohydratesDietary FatsFTO protein, humanMC4R protein, humanReceptor, Melanocortin, Type 4

Identifiers

PMID30032228
PMCPMC6054249

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.