ReviewAdvances in nutrition (Bethesda, Md.)2018
Caffeine in Kidney Stone Disease: Risk or Benefit?
Review in Advances in nutrition (Bethesda, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Causal effects of modifiable risk factors on kidney stones: a bidirectional mendelian randomization study.BMC medical genomics · 2023Pooled it
- Univariable and multivariable mendelian randomization study revealed the modifiable risk factors of urolithiasis.PloS one · 2023Pooled it
- Dietary and lifestyle factors for primary prevention of nephrolithiasis: a systematic review and meta-analysis.BMC nephrology · 2020Pooled it
- Assessing Risk of Nephrolithiasis in Urology Residents: Are We Practicing What We Preach?Cureus · 2026Article
- Systematic evaluation and comparison of theCurrent research in food science · 2026Article
- Dietary Influence on Urolithiasis Risk Mediated by Plasma Metabolites: A Mendelian Randomization and Experimental Study Linking Genes, Metabolites, and Clinical Outcomes.Food science & nutrition · 2025Article
- The Pandora's Box of Bariatric Surgery: Unveiling the Association with Kidney Stone Risk-A Cross-Sectional Study.Obesity surgery · 2025Article
- Ethnomedicinal Study and Evaluation of the Anxiolytic-like and Diuretic Effects of the OrchidPharmaceuticals (Basel, Switzerland) · 2024Article
- Diagnostic Ultrasound-Based Investigation of Central vs. Peripheral Arterial Changes Consequent to Low-Dose Caffeine Ingestion.Nutrients · 2024Article
- Article
- Comparing the risk factors of nephrolithiasis in Asian countries population: A systematic review and meta-analysis.Arab journal of urology · 2024Review
- Effects of coffee intake on airway hypersensitivity and immunomodulation: anNutrition research and practice · 2023Article
- Caffeine causes cell cycle arrest at G0/G1 and increases of ubiquitinated proteins, ATP and mitochondrial membrane potential in renal cells.Computational and structural biotechnology journal · 2023Article
- Correlation of Great Chinese Famine Exposure During Early Life to Prevalence of Kidney Stone in Adulthood.International journal of general medicine · 2023Article
- Betel Nut Chewing Is Associated with the Risk of Kidney Stone Disease.Journal of personalized medicine · 2022Article
- The Relationship Between Renal Stones and Primary Aldosteronism.Frontiers in endocrinology · 2022Article
- Computational Analysis of Influencing Factors and Multiple Scoring Systems of Stone Clearance Rate after Flexible Ureteroscopic Lithotripsy.Computational intelligence and neuroscience · 2022Article
- Consumption of Tea, Alcohol, and Fruits and Risk of Kidney Stones: A Prospective Cohort Study in 0.5 Million Chinese Adults.Nutrients · 2021Article
- Caffeine intake and the risk of recurrent kidney stones in adults, an analysis of 2007-2014 National Health and Nutrition Examination Surveys.European journal of nutrition · 2020Article
- Educational review: role of the pediatric nephrologists in the work-up and management of kidney stones.Pediatric nephrology (Berlin, Germany) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kidney stone disease is a global health care problem, with a high recurrence rate after stone removal. It is thus crucial to develop effective strategies to prevent the formation of new or recurrent stones. Caffeine is one of the main components in caffeinated beverages worldwide (i.e., coffee, tea, soft drinks, and energy drinks). Previous retrospective and prospective studies have reported contradictory effects of caffeine on kidney stone risk. Although it has a diuretic effect on enhancing urinary output, it may slightly increase the stone risk index. However, 3 large cohorts have suggested a preventive role of caffeine in kidney stone disease. In addition, a recent in vitro study has addressed relevant mechanisms underlying the preventive role of caffeine against stone pathogenesis. This review summarizes the relevant data from previous evidence and discusses the association between caffeine consumption and kidney stone risk reduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.