Evidence map›Paper›PMID 30032160›Full record

ArticleThe pharmacogenomics journal2019

Variation within voltage-gated calcium channel genes and antipsychotic treatment response in a South African first episode schizophrenia cohort.

Kevin S O'Connell, Nathaniel W McGregor, Anil Malhotra, Todd Lencz, Robin Emsley, Louise Warnich

Abstract read
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In one paragraph

Article in The pharmacogenomics journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. The role of calcium and CaMKII in sleep.Frontiers in systems neuroscience · 2022
    Review
  3. Review
  4. The Potential Role of Regulatory Genes (Frontiers in genetics · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Kevin S O'ConnellSystem Genetics Working Group, Department of Genetics, Faculty of AgriSciences, Stellenbosch University, Stellenbosch, South Africa.
Nathaniel W McGregorSystem Genetics Working Group, Department of Genetics, Faculty of AgriSciences, Stellenbosch University, Stellenbosch, South Africa.
Anil MalhotraDepartment of Psychiatry, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, New York, NY, USA.
Todd LenczDepartment of Psychiatry, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, New York, NY, USA.
Robin EmsleyDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Tygerberg Medical Campus, Tygerberg, Stellenbosch University, Stellenbosch, South Africa.
Louise WarnichDepartment of Genetics, Faculty of AgriSciences, Stellenbosch University, Stellenbosch, South Africa. lw@sun.ac.za.ORCID http://orcid.org/0000-0002-9331-998X
Stellenbosch University · ZANorthwell Health · US

Funding

National Research Foundation (NRF) 93498National Research Foundation (NRF) 93681
6 · The paper itself

Abstract

Voltage-gated calcium channels have been implicated in schizophrenia aetiology; however, little is known about their involvement in antipsychotic treatment response. This study investigated variants within the calcium channel subunit genes for association with antipsychotic treatment response in a first episode schizophrenia cohort. Twelve regulatory variants within seven genes were shown to be significantly associated with treatment outcome. Most notably, the CACNA1B rs2229949 CC genotype was associated with improved negative symptomology, where the C allele was predicted to abolish a miRNA-binding site (has-mir-5002-3p), suggesting a possible mechanism of action through which this variant may have an effect. These results implicate the calcium channel subunits in antipsychotic treatment response and suggest that increased activation of these channels may be explored to enhance or predict antipsychotic treatment outcome.

Indexed as

AllelesAntipsychotic AgentsBlack PeopleCalcium ChannelsCalcium Channels, N-TypeCohort StudiesGenotypeHumansPolymorphism, Single NucleotideSchizophreniaTreatment OutcomeAntipsychotic AgentsCalcium ChannelsCalcium Channels, N-Type

Identifiers

PMID30032160
OpenAlexW2883208403

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.