ArticleNeurobiology of aging2018
Dissociable effects of advanced age on prefrontal cortical and medial temporal lobe ensemble activity.
Article in Neurobiology of aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 31 citations in OpenAlex.
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- Experience-Dependent Effects of Muscimol-Induced Hippocampal Excitation on Mnemonic Discrimination.Frontiers in systems neuroscience · 2018Article
- Perforant Path Fiber Loss Results in Mnemonic Discrimination Task Deficits in Young Rats.Frontiers in systems neuroscience · 2018Article
- A Ketogenic Diet Improves Cognition and Has Biochemical Effects in Prefrontal Cortex That Are Dissociable From Hippocampus.Frontiers in aging neuroscience · 2018Article
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11 authors at 2 institutions in 1 country.
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Abstract
The link between age-related cellular changes within brain regions and larger scale neuronal ensemble dynamics critical for cognition has not been fully elucidated. The present study measured neuron activity within medial prefrontal cortex (PFC), perirhinal cortex (PER), and hippocampal subregion CA1 of young and aged rats by labeling expression of the immediate-early gene Arc. The proportion of cells expressing Arc was quantified at baseline and after a behavior that requires these regions. In addition, PER and CA1 projection neurons to PFC were identified with retrograde labeling. Within CA1, no age-related differences in neuronal activity were observed in the entire neuron population or within CA1 pyramidal cells that project to PFC. Although behavior was comparable across age groups, behaviorally driven Arc expression was higher in the deep layers of both PER and PFC and lower in the superficial layers of these regions. Moreover, age-related changes in activity levels were most evident within PER cells that project to PFC. These data suggest that the PER-PFC circuit is particularly vulnerable in advanced age.
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