Evidence map›Paper›PMID 30031768›Full record

ArticleGastroenterology2018

Effects of Organized Colorectal Cancer Screening on Cancer Incidence and Mortality in a Large Community-Based Population.

Theodore R Levin, Douglas A Corley, Christopher D Jensen, Joanne E Schottinger, Virginia P Quinn, Ann G Zauber, Jeffrey K Lee, Wei K Zhao, Natalia Udaltsova, Nirupa R Ghai and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 299 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
299citing papers in PubMed, 5 pooled it
19.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

299 citing papers in PubMed, 5 syntheses or guidelines pooled it, 551 citations in OpenAlex.

  1. Pooled it
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  6. Behavioral Interventions Improve Mailed Colorectal Cancer Screening Among Overdue Patients in a Randomized Trial.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026
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239 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Theodore R LevinKaiser Permanente Medical Center, Walnut Creek, California; Division of Research, Kaiser Permanente Northern California, Oakland, California. Electronic address: theodore.levin@kp.org.
Douglas A CorleyDivision of Research, Kaiser Permanente Northern California, Oakland, California.
Christopher D JensenDivision of Research, Kaiser Permanente Northern California, Oakland, California.
Joanne E SchottingerDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California.
Virginia P QuinnDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California.
Ann G ZauberDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
Jeffrey K LeeDivision of Research, Kaiser Permanente Northern California, Oakland, California.
Wei K ZhaoDivision of Research, Kaiser Permanente Northern California, Oakland, California.
Natalia UdaltsovaDivision of Research, Kaiser Permanente Northern California, Oakland, California.
Nirupa R GhaiDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California.
Alexander T LeeDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California.
Charles P QuesenberryDivision of Research, Kaiser Permanente Northern California, Oakland, California.
Bruce H FiremanDivision of Research, Kaiser Permanente Northern California, Oakland, California.
Chyke A DoubeniDepartment of Family Medicine and Community Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Kaiser Permanente · USMemorial Sloan Kettering Cancer Center · USUniversity of Pennsylvania · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Optimizing Colorectal Cancer Screening PREcision and Outcomes in CommunIty-baSEd Populations (PRECISE)UM1CA222035 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI CHUBAK, JESSICA, CORLEY, DOUGLAS ALLEN · 2018 to 2023
$15.6M
Optimizing the use of colonoscopy for CRC screening in a large community-basedU54CA163262 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI CORLEY, DOUGLAS ALLEN, DOUBENI, CHYKE ABADAMA · 2011 to 2017
$9.6M
Effectiveness of screening for colorectal cancer in average risk adults: Colonoscopy vs. FITR01CA213645 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CORLEY, DOUGLAS ALLEN, DOUBENI, CHYKE ABADAMA · 2017 to 2021
$3.2M
Optimizing long-term post-polypectomy surveillance for colorectal cancer prevention using a prediction rule developed from a large, community-based cohortK07CA212057 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, JEFFREY KUANG ZOU · 2016 to 2020
$869k
NCI NIH HHS K07 CA212057NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA213645NCI NIH HHS U54 CA163262NCI NIH HHS UM1 CA222035
6 · The paper itself

Abstract

BACKGROUND &

aimsLittle information is available on the effectiveness of organized colorectal cancer (CRC) screening on screening uptake, incidence, and mortality in community-based populations.

methodsWe contrasted screening rates, age-adjusted annual CRC incidence, and incidence-based mortality rates before (baseline year 2000) and after (through 2015) implementation of organized screening outreach, from 2007 through 2008 (primarily annual fecal immunochemical testing and colonoscopy), in a large community-based population. Among screening-eligible individuals 51-75 years old, we calculated annual up-to-date status for cancer screening (by fecal test, sigmoidoscopy, or colonoscopy), CRC incidence, cancer stage distributions, and incidence-based mortality.

resultsInitiation of organized CRC screening significantly increased the up-to-date status of screening, from 38.9% in 2000 to 82.7% in 2015 (P < .01). Higher rates of screening were associated with a 25.5% reduction in annual CRC incidence between 2000 and 2015, from 95.8 to 71.4 cases/100,000 (P < .01), and a 52.4% reduction in cancer mortality, from 30.9 to 14.7 deaths/100,000 (P < .01). Increased screening was initially associated with increased CRC incidence, due largely to greater detection of early-stage cancers, followed by decreases in cancer incidence. Advanced-stage CRC incidence rates decreased 36.2%, from 45.9 to 29.3 cases/100,000 (P < .01), and early-stage CRC incidence rates decreased 14.5%, from 48.2 to 41.2 cases/100,000 (P < .04).

conclusionsImplementing an organized CRC screening program in a large community-based population rapidly increased screening participation to the ≥80% target set by national organizations. Screening rates were sustainable and associated with substantial decreases in CRC incidence and mortality within short time intervals, consistent with early detection and cancer prevention.

Indexed as

Early Detection of CancerAgedColonoscopyColorectal NeoplasmsFemaleHumansIncidenceMaleMiddle AgedOccult BloodColon CancerEarly DetectionFITNeoplasm

Identifiers

PMID30031768
PMCPMC6240353
OpenAlexW2883374138

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.