Evidence map›Paper›PMID 30031745›Full record

ArticleThe Journal of investigative dermatology2019

Outcomes and Risk Factors in Patients with Multiple Primary Melanomas.

Adi Nosrati, Wesley Y Yu, Joseph McGuire, Ann Griffin, Juliana Rocha de Souza, Rasnik Singh, Eleni Linos, Mary Margaret Chren, Barbara Grimes, Nicholas P Jewell and 1 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Adi NosratiDepartment of Dermatology, University of California, San Francisco, San Francisco, California, USA; Dermatology Service, Veterans Affairs Medical Center, San Francisco, California, USA.
Wesley Y YuDepartment of Dermatology, University of California, San Francisco, San Francisco, California, USA; Dermatology Service, Veterans Affairs Medical Center, San Francisco, California, USA.
Joseph McGuireHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA.
Ann GriffinHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA.
Juliana Rocha de SouzaDepartment of Dermatology, University of California, San Francisco, San Francisco, California, USA.
Rasnik SinghDepartment of Dermatology, University of California, San Francisco, San Francisco, California, USA.
Eleni LinosDepartment of Dermatology, University of California, San Francisco, San Francisco, California, USA; Program for Clinical Research, Department of Dermatology, University of California, San Francisco, San Francisco, California, USA.
Mary Margaret ChrenDepartment of Dermatology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Barbara GrimesDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Nicholas P JewellDepartments of Biostatistics and Statistics, University of California, Berkeley, Berkeley, California, USA.
Maria L WeiDepartment of Dermatology, University of California, San Francisco, San Francisco, California, USA; Dermatology Service, Veterans Affairs Medical Center, San Francisco, California, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA; Program for Clinical Research, Department of Dermatology, University of California, San Francisco, San Francisco, California, USA. Electronic address: maria.wei@ucsf.edu.

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Involving older adults in decision making for skin cancerK76AG054631 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LINOS, ELENI · 2016 to 2018
$644k
Online Advertising for Skin Cancer PreventionR21CA212201 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LINOS, ELENI · 2017 to 2018
$379k
Statistical Design and Analysis of Cluster Randomized Test-Negative Designs: Studies to Eliminate Dengue FeverR56AI134724 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI JEWELL, NICHOLAS P · 2018 to 2018
$187k
NCATS NIH HHS UL1 TR000004NCI NIH HHS R21 CA212201NIAID NIH HHS R56 AI134724NIA NIH HHS K76 AG054631
6 · The paper itself

Abstract

The incidence and patient survival rates of melanoma have increased over the last several decades, with a growing population of patients who develop multiple primary melanomas (MPMs). To determine risk factors for developing MPMs and compare the survival of patients with MPMs to those with single primary melanomas, a prospective, multidisciplinary database of patients with melanoma at a single tertiary care institution was retrospectively reviewed. From 1985 to 2013, 6,963 patients with single primary melanomas and 305 patients with MPMs were identified. Mean follow-up was 8.3 ± 6.3 years for patients with single primary melanomas and 8.8 ± 5.9 years for patients with MPMs. Risk of developing multiple melanomas increased with age at diagnosis of first melanoma (hazard ratio [HR] = 1.20 for a 10-year increase in age, 95% confidence interval [CI] = 1.11-1.29, P < 0.001), male sex (HR = 1.44, 95% CI = 1.12-1.84, P = 0.005), and white race (HR = 3.07, 95% CI = 1.45-6.51). Patients with invasive MPMs had increased risk of melanoma-specific death both before (HR = 1.47, 95% CI = 1.0-2.2) and after adjusting for age, sex, site, race, family history of melanoma, personal history of other cancer, and Surveillance, Epidemiology, and End Results Program (SEER) stage (HR = 1.44, 95% CI = 0.95-2.2); however, this result did not reach statistical significance.

Indexed as

Neoplasm StagingRegistriesRisk AssessmentCutaneous Malignant MelanomaFemaleHumansIncidenceMaleMelanomaMiddle AgedNeoplasms, Multiple PrimaryPrognosisRetrospective StudiesRisk FactorsSkin NeoplasmsSurvival Rate

Identifiers

PMID30031745
PMCPMC9191767

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.