Evidence map›Paper›PMID 30031688›Full record

ArticleMolecular genetics and metabolism2018

Tissue acylcarnitine status in a mouse model of mitochondrial β-oxidation deficiency during metabolic decompensation due to influenza virus infection.

Tatiana N Tarasenko, Kristina Cusmano-Ozog, Peter J McGuire

Abstract read
In one paragraph

Article in Molecular genetics and metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. A review of fatty acid oxidation disorder mouse models.Molecular genetics and metabolism · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Urine Metabolite of Mice with Orientia tsutsugamushi Infection.The American journal of tropical medicine and hygiene · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Tatiana N TarasenkoMetabolism, Infection and Immunity Section, National Human Genome Research Institute, National Institutes of Health, United States.
Kristina Cusmano-OzogRare Disease Institute, Children's National Medical Center, Washington, DC, United States.
Peter J McGuireMetabolism, Infection and Immunity Section, National Human Genome Research Institute, National Institutes of Health, United States. Electronic address: peter.mcguire@nih.gov.
Children's National · USNational Human Genome Research Institute · USNational Institutes of Health · US

Funding

Metabolism, infection and immunity in inborn errors of mitochondrial metabolismZIAHG200381 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI MCGUIRE, PETER · 2012 to 2025
$21.7M
Intramural NIH HHS ZIA HG200381
6 · The paper itself

Abstract

Despite judicious monitoring and care, patients with fatty acid oxidation disorders may experience metabolic decompensation due to infection which may result in rhabdomyolysis, cardiomyopathy, hypoglycemia and liver dysfunction and failure. Since clinical studies on metabolic decompensation are dangerous, we employed a preclinical model of metabolic decompensation due to infection. By infecting mice with mouse adapted influenza and using a pair-feeding strategy in a mouse model of long-chain fatty acid oxidation (Acadvl

Indexed as

Acyl-CoA Dehydrogenase, Long-ChainAnimalsCardiomyopathiesCarnitineCongenital Bone Marrow Failure SyndromesDisease Models, AnimalFatty AcidsFemaleHumansHypoglycemiaLipid Metabolism, Inborn ErrorsLipid PeroxidationLiverLiver FailureMetabolic DiseasesMiceacylcarnitineAcyl-CoA Dehydrogenase, Long-ChainCarnitineFatty AcidsAcylcarnitinesBiochemical geneticsFatty acid oxidationHeartInfectionInfluenzaLiverMetabolic decompensationMusclePlasmaVery long-chain acyl CoA dehydrogenase deficiency

Identifiers

PMID30031688
PMCPMC6626496
OpenAlexW2809789630

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.