ArticleMicrobiome2018
Conserved phylogenetic distribution and limited antibiotic resistance of class 1 integrons revealed by assessing the bacterial genome and plasmid collection.
Article in Microbiome, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 113 citations in OpenAlex.
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- Inter-plasmid transfer of antibiotic resistance genes accelerates antibiotic resistance in bacterial pathogens.The ISME journal · 2024Article
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- Tackling Soil ARG-Carrying Pathogens with Global-Scale Metagenomics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Comparative genomics of trimethoprim-sulfamethoxazole-resistant Achromobacter xylosoxidans clinical isolates from Serbia reveals shortened variant of class 1 integron integrase gene.Folia microbiologica · 2023Article
- Quantification of the mobility potential of antibiotic resistance genes through multiplexed ddPCR linkage analysis.FEMS microbiology ecology · 2023Article
- Population-level impacts of antibiotic usage on the human gut microbiome.Nature communications · 2023Article
- The fate of sulfonamide resistance genes and anthropogenic pollution markerFrontiers in microbiology · 2023Article
- Antibiotic resistance indicator genes in biofilm and planktonic microbial communities after wastewater discharge.Frontiers in microbiology · 2023Article
- ARGem: a new metagenomics pipeline for antibiotic resistance genes: metadata, analysis, and visualization.Frontiers in genetics · 2023Article
- Geospatial Patterns of Antimicrobial Resistance Genes in the US EPA National Rivers and Streams Assessment Survey.Environmental science & technology · 2022Article
- Antimicrobial resistance-Do we share more than companionship with our dogs?Journal of applied microbiology · 2022Article
- Metagenomic tracking of antibiotic resistance genes through a pre-harvest vegetable production system: an integrated lab-, microcosm- and greenhouse-scale analysis.Environmental microbiology · 2022Article
- PCycDB: a comprehensive and accurate database for fast analysis of phosphorus cycling genes.Microbiome · 2022Article
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Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntegrons, especially the class 1 integrons, are major contributors to the acquisition and dissemination of antibiotic resistance genes (ARGs). However, comprehensive knowledge of the types, content, and distribution of integrons in bacterial taxa is lacking to evaluate their contribution.
resultsWe have constructed a new integrase database and developed a pipeline that provides comprehensive recovery of class 1 integrons. Previous PCR-based techniques might only detect one fourth of the integron-integrases and integrons recovered in this study. By exploring the class 1 integrons in over 73,000 currently available complete and draft bacterial genomes, the contribution of class 1 integrons in spreading and acquiring ARGs was evaluated. Firstly, the host species of class 1 integrons are highly conserved within (96%) in class Gammaproteobacteria, dominated by four pathogenic species of "ESKAPE." Secondly, more than half of class 1 integrons are embedded in chromosomes with less potential for horizontal gene transfer. Finally, ARGs that have been acquired by these integrons only cover 11% of all the ARG genotypes detected in bacterial genomes.
conclusionsThe above observations indicated that there are both biological and ecological limitations to class 1 integrons in acquiring and spreading ARGs across different classes of the domain Bacteria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.