Evidence map›Paper›PMID 30031105›Full record

ReviewMolecular and cellular neurosciences2018

EphBs and ephrin-Bs: Trans-synaptic organizers of synapse development and function.

Nathan T Henderson, Matthew B Dalva

Abstract readReview
In one paragraph

Review in Molecular and cellular neurosciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 81 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Eph receptor signaling complexes in the plasma membrane.Trends in biochemical sciences · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Nathan T HendersonThe Jefferson Synaptic Biology Center, Department of Neuroscience, The Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Jefferson Hospital for Neuroscience, Suite 463, 900 Walnut St., Philadelphia, PA 19107, United States.
Matthew B DalvaThe Jefferson Synaptic Biology Center, Department of Neuroscience, The Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Jefferson Hospital for Neuroscience, Suite 463, 900 Walnut St., Philadelphia, PA 19107, United States. Electronic address: matthew.dalva@jefferson.edu.
Jefferson Hospital for Neuroscience · USThomas Jefferson University · US

Funding

Cell-Contact Mediated Mechanisms Assembling Synapses (R01DA022727)R01DA022727 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI DALVA, MATTHEW B · 2007 to 2025
$5.2M
Examining the Function of Biological Sex Specific Genes: the NLGN4sR01NS106906 · NINDS · TULANE UNIVERSITY OF LOUISIANA · PI DALVA, MATTHEW B · 2018 to 2022
$2.1M
Glial Control of Neuronal Progenitor Cell MigrationR01MH100093 · NIMH · THOMAS JEFFERSON UNIVERSITY · PI DALVA, MATTHEW B · 2013 to 2017
$1.9M
NIDA NIH HHS R01 DA022727NIMH NIH HHS R01 MH100093NINDS NIH HHS R01 NS106906
6 · The paper itself

Abstract

Synapses are specialized cell-cell junctions that underlie the function of neural circuits by mediating communication between neurons. Both the formation and function of synapses require tight coordination of signaling between pre- and post-synaptic neurons. Trans-synaptic organizing molecules are important mediators of such signaling. Here we discuss how the EphB and ephrin-B families of trans-synaptic organizing proteins direct synapse formation during early development and regulate synaptic function and plasticity at mature synapses. Finally, we highlight recent evidence linking the synaptic organizing role of EphBs and ephrin-Bs to diseases of maladaptive synaptic function and plasticity.

Indexed as

AnimalsEphrinsHumansNeurogenesisReceptors, Eph FamilySynapsesSynaptic TransmissionEphrinsReceptors, Eph FamilyEphrinsEphsMaladaptive plasticityNeuropathic painSynaptic plasticitySynaptogenesis

Identifiers

PMID30031105
PMCPMC6159941
OpenAlexW2883824321

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.